Telomerase reactivation in malignant gliomas and loss of heterozygosity on 10p15.1

Telomerase reactivation in malignant gliomas and loss of heterozygosity on 10p15.1

An inhibitor of telomerase activity maps to chromosome 10p15.1. A series of 51 high-grade gliomas was analyzed for loss of heterozygosity (LOH) on chromosome 10 and for telomerase activity. In univariate analysis, LOH10p (59%) and LOH10q (61%) were associated with telomerase activity (55%; p < 0....

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Veröffentlicht in:Neurology 2003-06, Vol.60 (11), p.1820-1822
Hauptverfasser: Leuraud, P, Aguirre-Cruz, L, Hoang-Xuan, K, Crinière, E, Tanguy, M-L, Golmard, J-L, Kujas, M, Delattre, J-Y, Sanson, M
Format: Artikel
Sprache:eng
Schlagworte:
Chromosome Mapping
Chromosomes, Human, Pair 10
Glioma - enzymology
Glioma - genetics
Humans
Loss of Heterozygosity
Telomerase - metabolism
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Zusammenfassung:An inhibitor of telomerase activity maps to chromosome 10p15.1. A series of 51 high-grade gliomas was analyzed for loss of heterozygosity (LOH) on chromosome 10 and for telomerase activity. In univariate analysis, LOH10p (59%) and LOH10q (61%) were associated with telomerase activity (55%; p < 0.0001 and p = 0.0006). In multivariate analysis, only LOH10p remained statistically related to telomerase activity, suggesting that the telomerase repressor gene located on 10p15.1 is inactivated in high-grade gliomas.
ISSN:0028-3878
1526-632X
DOI:10.1212/01.WNL.0000065894.89082.5E