Protein Kinase C/Mitogen-Activated Protein Kinase Signaling in Keratinocyte Differentiation Control

Protein Kinase C/Mitogen-Activated Protein Kinase Signaling in Keratinocyte Differentiation Control

Proper epidermal keratinocyte differentiation, which is necessary for cutaneous barrier function, is altered in many common skin diseases. Keratinocyte differentiation is controlled by a complex signaling network involving multiple members of the protein kinase C and mitogen-activated protein kinase...

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Veröffentlicht in:Journal of investigative dermatology 2010-08, Vol.130 (8), p.1968-1970
1. Verfasser: Denning, Mitchell F.
Format: Artikel
Sprache:eng
Schlagworte:
Cell Differentiation - physiology
Humans
Keratinocytes - cytology
Keratinocytes - metabolism
Mitogen-Activated Protein Kinases - metabolism
Protein Kinase C - metabolism
Signal Transduction - physiology
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Zusammenfassung:Proper epidermal keratinocyte differentiation, which is necessary for cutaneous barrier function, is altered in many common skin diseases. Keratinocyte differentiation is controlled by a complex signaling network involving multiple members of the protein kinase C and mitogen-activated protein kinase signaling kinases. Using an RNA interference knockdown approach, Adhikary et al. identified essential nodes in this signaling network, revealing remarkable kinase specificity.
ISSN:0022-202X
1523-1747
DOI:10.1038/jid.2010.194