Antimycobacterial Activity of 1-Substituted Indolizines

Indolizine derivatives were tested as antimycobacterials against Mycobacterium tuberculosis H37Rv (ATCC 27294)in BACTEC 12B medium using the Microplate Alamar Blue Assay. The most active compounds examined carry an α‐hydroxybenzyl substituent in the indolizine 1‐position. MICs against Mycobacterium...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 2003-06, Vol.336 (3), p.191-195
Hauptverfasser:	Gundersen, Lise-Lotte, Negussie, Ayele H., Rise, Frode, Østby, Ole Benny
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antimycobacterial Antitubercular Agents - chemical synthesis Antitubercular Agents - chemistry Antitubercular Agents - pharmacology Biological and medical sciences Indolizines Indolizines - chemical synthesis Indolizines - chemistry Indolizines - pharmacology Medical sciences Microbial Sensitivity Tests Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Pharmacology. Drug treatments Structure-Activity Relationship Tuberculosis
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Zusammenfassung:	Indolizine derivatives were tested as antimycobacterials against Mycobacterium tuberculosis H37Rv (ATCC 27294)in BACTEC 12B medium using the Microplate Alamar Blue Assay. The most active compounds examined carry an α‐hydroxybenzyl substituent in the indolizine 1‐position. MICs against Mycobacterium tuberculosis for these compounds were 6.25 μg/mL
ISSN:	0365-6233 1521-4184
DOI:	10.1002/ardp.200390019