Thiazole analog as stearoyl-CoA desaturase 1 inhibitor

A prototype thiazole amide analog 13 ( MF-152) was identified as an excellent tool in the study of SCD biology in animals. SCD1 inhibition may represent a novel treatment for obesity, type-2 diabetes and related metabolic disorders. A prototype thiazole amide analog 13 ( MF-152) was identified as an...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-09, Vol.19 (17), p.5214-5217
Hauptverfasser:	Li, Chun Sing, Belair, Liette, Guay, Jocelyne, Murgasva, Renata, Sturkenboom, Wayne, Ramtohul, Yeeman K., Zhang, Lei, Huang, Zheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological and medical sciences Cell Line, Tumor Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology General and cellular metabolism. Vitamins Humans Hypoglycemic Agents - chemical synthesis Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Medical sciences MF-152 Mice Mice, Inbred C57BL Mice, Knockout Obesity Pharmacology. Drug treatments Piperazines - chemical synthesis Piperazines - chemistry Piperazines - pharmacology Rats SCD1 Stearoyl-CoA Desaturase - antagonists & inhibitors Stearoyl-CoA Desaturase - metabolism Stearoyl-CoA desaturase 1 inhibitor Thiazole Thiazoles - chemical synthesis Thiazoles - chemistry Thiazoles - pharmacology Type-2 diabetes
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Zusammenfassung:	A prototype thiazole amide analog 13 ( MF-152) was identified as an excellent tool in the study of SCD biology in animals. SCD1 inhibition may represent a novel treatment for obesity, type-2 diabetes and related metabolic disorders. A prototype thiazole amide analog 13 ( MF-152) was identified as an excellent tool in the study of SCD biology in animals.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2009.07.015