MOLECULAR DESIGN OF BIOLOGICALLY ACTIVE COMPOUNDS BASED ON PLATELET ACTIVATING FACTOR (PAF) : 7-OXABICYCLO[2.2.1]HEPTANE SYSTEM AS A STRONG ANTAGONIST OF PAF

7-Oxabicyclo[2.2.1]heptane system was designed based on the PAF structure. Among four stereoisomers synthesized, the diexo derivative turned out to be a new and strong antagonist of PAF.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 1992/10/25, Vol.40(10), pp.2891-2893
Hauptverfasser:	KOBAYASHI, Susumu, EGUCHI, Yoshihito, SATO, Michitaka, KUDO, Ichiro, INOUE, Keizo, OHNO, Masaji
Format:	Artikel
Sprache:	eng
Schlagworte:	7-oxabicyclo[2.2.1]heptane antagonist Chemistry Drug Design Exact sciences and technology Heptanes - chemical synthesis Heptanes - pharmacology Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives molecular design Organic chemistry PAF platelet activating factor Platelet Activating Factor - antagonists & inhibitors Platelet Activating Factor - chemistry Platelet Aggregation Inhibitors - chemistry Preparations and properties Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	7-Oxabicyclo[2.2.1]heptane system was designed based on the PAF structure. Among four stereoisomers synthesized, the diexo derivative turned out to be a new and strong antagonist of PAF.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.40.2891