Autologous Transplantation of Bone Marrow Mononuclear Cells Improved Ischemic Peripheral Neuropathy in Humans

[...]we examined whether autologous transplantation of BM-MNCs would improve ischemic neuropathy with critical limb ischemia in humans. Furthermore, BM-MNC transplantation improved objective peripheral nerve functions (MNCV, CMAP, and QVT) in the treated limb but not in the control limb, suggesting...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American College of Cardiology 2010-07, Vol.56 (3), p.238-239
Hauptverfasser:	Arima, Ken, MD, Katsuda, Yousuke, MD, PhD, Takeshita, Yoshiaki, MD, PhD, Saito, Yutaka, MD, PhD, Toyama, Yasuyuki, MD, Katsuki, Yoshio, MD, Ootsuka, Masanori, MD, Koiwaya, Hiroshi, MD, Sasaki, Ken-ichiro, MD, PhD, Kai, Hisashi, MD, PhD, Imaizumi, Tsutomu, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Arterial Occlusive Diseases - complications Biological and medical sciences Bone marrow Bone Marrow Transplantation Cardiology Cardiology. Vascular system Cardiovascular Humans Internal Medicine Ischemia Medical imaging Medical sciences Middle Aged Pain Peripheral Nervous System Diseases - surgery Transplantation, Autologous Transplants & implants Vascular endothelial growth factor
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	[...]we examined whether autologous transplantation of BM-MNCs would improve ischemic neuropathy with critical limb ischemia in humans. Furthermore, BM-MNC transplantation improved objective peripheral nerve functions (MNCV, CMAP, and QVT) in the treated limb but not in the control limb, suggesting that the effects were not related to natural course or nonspecific effects. [...]autologous BM-MNC transplantation might improve not only peripheral blood perfusion but also ischemic peripheral neuropathy.
ISSN:	0735-1097 1558-3597
DOI:	10.1016/j.jacc.2010.02.050