The biology and evolution of transposable elements in parasites

Transposable elements (TEs) are dynamic elements that can reshape host genomes by generating rearrangements with the potential to create or disrupt genes, to shuffle existing genes, and to modulate their patterns of expression. In the genomes of parasites that infect mammals several TEs have been id...

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Veröffentlicht in:Trends in parasitology 2010-07, Vol.26 (7), p.350-362
Hauptverfasser: Thomas, M. Carmen, Macias, Francisco, Alonso, Carlos, López, Manuel C
Format: Artikel
Sprache:eng
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Zusammenfassung:Transposable elements (TEs) are dynamic elements that can reshape host genomes by generating rearrangements with the potential to create or disrupt genes, to shuffle existing genes, and to modulate their patterns of expression. In the genomes of parasites that infect mammals several TEs have been identified that probably have been maintained throughout evolution due to their contribution to gene function and regulation of gene expression. This review addresses how TEs are organized, how they colonize the genomes of mammalian parasites, the functional role these elements play in parasite biology, and the interactions between these elements and the parasite genome.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2010.04.001