Complex of cyclosporins produced by Tolypocladium inflatum isolated from soil sample from Buriatiia

Complex of cyclosporins produced by Tolypocladium inflatum isolated from soil sample from Buriatiia

A micromycete culture was isolated from a soil sample of Buryatiya and identified as Tolypocladium inflatum No. 2. The culture was shown to produce a complex of cyclosporins of unusual component structure: the content of cyclosporin A (55-60%) was the same as that in the substances produced by the m...

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Veröffentlicht in:Antibiotiki i himioterapiâ 2009, Vol.54 (9-10), p.6-9
Hauptverfasser: Bibikova, M V, Darkhanova, T A, Spiridonova, I A, Danilenko, A N, Katlinskiĭ, A V
Format: Artikel
Sprache:rus
Schlagworte:
Cyclosporins - isolation & purification
Hypocreales - chemistry
Immunosuppressive Agents - isolation & purification
Siberia
Soil Microbiology
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Zusammenfassung:A micromycete culture was isolated from a soil sample of Buryatiya and identified as Tolypocladium inflatum No. 2. The culture was shown to produce a complex of cyclosporins of unusual component structure: the content of cyclosporin A (55-60%) was the same as that in the substances produced by the majority of the described cultures, the content of cyclosporin B was much higher (about 40%) and the content of cyclosporin C was relatively low (about 3%). An appreciable content of cyclosporin (Leu4)Cs (3%) proved to be of interest.
ISSN:0235-2990