Labyrinthopeptins: A New Class of Carbacyclic Lantibiotics

Labyrinthopeptins: A New Class of Carbacyclic Lantibiotics

A‐maze‐ing peptides: The structure of the novel lantibiotic labyrinthopeptin A2 (see picture) contains labionin—an unprecedented carbacyclic, posttranslationally modified amino acid. The identification of the biosynthetic gene cluster of labyrinthopeptins was also successful. Labyrinthopeptin A2 rev...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2010-02, Vol.49 (6), p.1151-1154
Hauptverfasser: Meindl, Kathrin, Schmiederer, Timo, Schneider, Kathrin, Reicke, Andreas, Butz, Diane, Keller, Simone, Gühring, Hans, Vértesy, László, Wink, Joachim, Hoffmann, Holger, Brönstrup, Mark, Sheldrick, George M, Süssmuth, Roderich D
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
antibiotics
antipain activity
Bacteriocins - biosynthesis
Bacteriocins - chemistry
Bacteriocins - genetics
lanthionine
lantibiotics
Models, Molecular
Molecular Sequence Data
Multigene Family
peptides
Protein Structure, Tertiary
Streptomyces coelicolor - chemistry
Streptomyces coelicolor - genetics
Streptomyces coelicolor - metabolism
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Zusammenfassung:A‐maze‐ing peptides: The structure of the novel lantibiotic labyrinthopeptin A2 (see picture) contains labionin—an unprecedented carbacyclic, posttranslationally modified amino acid. The identification of the biosynthetic gene cluster of labyrinthopeptins was also successful. Labyrinthopeptin A2 revealed a pronounced in vivo efficacy (attenuation of tactile allodynia) in a mouse model of neuropathic pain.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200905773