Copper-Catalyzed Direct Alkenylation of N-Iminopyridinium Ylides

Copper-Catalyzed Direct Alkenylation of N-Iminopyridinium Ylides

A versatile Cu‐catalyzed direct CH alkenylation of N‐iminopyridinium ylides, compatible with several different copper sources (including a penny), provides a powerful and inexpensive method for the synthesis of functionalized pyridine derivatives. Chemoselective functionalization of halide‐containi...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2010-02, Vol.49 (6), p.1115-1118
Hauptverfasser: Mousseau, James J, Bull, James A, Charette, André B
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes - chemistry
bioactivity
Catalysis
copper
Copper - chemistry
heterocycles
homogeneous catalysis
Imines - chemistry
Molecular Structure
Pyridinium Compounds - chemical synthesis
vinylidene ligands
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Zusammenfassung:A versatile Cu‐catalyzed direct CH alkenylation of N‐iminopyridinium ylides, compatible with several different copper sources (including a penny), provides a powerful and inexpensive method for the synthesis of functionalized pyridine derivatives. Chemoselective functionalization of halide‐containing compounds allows the synthesis of alkenyl pyridines containing reactive tethers for further functionalization.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200906020