Drug Design for G-Protein-Coupled Receptors by a Ligand-Based NMR Method

Drug Design for G-Protein-Coupled Receptors by a Ligand-Based NMR Method

A nonradioactive binding assay relying on NMR methods has been devised for a G‐protein‐coupled receptor; in addition the INPHARMA methods give access to the relative orientation of multiple ligands and supports ligand‐based drug design (see picture of superimposed ligands). The method is fast and do...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie (International ed.) 2010-02, Vol.49 (8), p.1426-1429
Hauptverfasser: Bartoschek, Stefan, Klabunde, Thomas, Defossa, Elisabeth, Dietrich, Viktoria, Stengelin, Siegfried, Griesinger, Christian, Carlomagno, Teresa, Focken, Ingo, Wendt, K. Ulrich
Format: Artikel
Sprache:eng
Schlagworte:
Drug Design
G-protein-coupled receptors
Ligands
Magnetic Resonance Spectroscopy - methods
Molecular Structure
NMR spectroscopy
Quantitative Structure-Activity Relationship
Receptors, G-Protein-Coupled - chemistry
structure-activity relationships
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A nonradioactive binding assay relying on NMR methods has been devised for a G‐protein‐coupled receptor; in addition the INPHARMA methods give access to the relative orientation of multiple ligands and supports ligand‐based drug design (see picture of superimposed ligands). The method is fast and does not require any structural information from protein crystal structures.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200905102