A selective electrochemical method of glycosylation of 3beta-hydroxy-Delta 5-steroids

A selective electrochemical method of glycosylation of 3beta-hydroxy-Delta 5-steroids

A new electrochemical glycosylation method is presented. According to the method cholesterol and other 3beta-hydroxy-Delta(5)-steroids can be selectively transformed to glycosides using non-activated sugars. The method is also useful for the synthesis of glycoconjugates with sugar linked to a steroi...

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Veröffentlicht in:Carbohydrate research 2010-05, Vol.345 (8), p.1051-1055
Hauptverfasser: Morzycki, Jacek W, Łotowski, Zenon, Siergiejczyk, Leszek, Wałejko, Piotr, Witkowski, Stanisław, Kowalski, Jan, Płoszyńska, Jolanta, Sobkowiak, Andrzej
Format: Artikel
Sprache:eng
Schlagworte:
Electrochemistry - methods
Glycosides - chemical synthesis
Glycosides - chemistry
Glycosylation
Molecular Structure
Steroids - chemistry
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Zusammenfassung:A new electrochemical glycosylation method is presented. According to the method cholesterol and other 3beta-hydroxy-Delta(5)-steroids can be selectively transformed to glycosides using non-activated sugars. The method is also useful for the synthesis of glycoconjugates with sugar linked to a steroid moiety by an ether bond.
ISSN:1873-426X
DOI:10.1016/j.carres.2010.03.018