Mechanisms of RNA Degradation by the Eukaryotic Exosome

Mechanisms of RNA Degradation by the Eukaryotic Exosome

RNA on its way to destruction: The exosome is a multi‐subunit protein complex involved in essentially all phenomena associated with RNA metabolism in eukaryotic cells. This review discusses recent discoveries in the fields of biochemistry and structural biology that have shed new light on the mechan...

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Veröffentlicht in:Chembiochem : a European journal of chemical biology 2010-05, Vol.11 (7), p.938-945
Hauptverfasser: Tomecki, Rafal, Drazkowska, Karolina, Dziembowski, Andrzej
Format: Artikel
Sprache:eng
Schlagworte:
Biocatalysis
Catalytic Domain
Exoribonucleases - chemistry
Exoribonucleases - metabolism
exosome
Exosome Multienzyme Ribonuclease Complex
hydrolases
RNA
RNA - metabolism
RNA degradation
RNase
Saccharomyces cerevisiae Proteins - metabolism
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Zusammenfassung:RNA on its way to destruction: The exosome is a multi‐subunit protein complex involved in essentially all phenomena associated with RNA metabolism in eukaryotic cells. This review discusses recent discoveries in the fields of biochemistry and structural biology that have shed new light on the mechanisms of RNA recruitment to the catalytic subunits of the exosome.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.201000025