Association of thymic stromal lymphopoietin gene −847C>T polymorphism in generalized vitiligo

s: Thymic stromal lymphopoietin (TSLP) induces naïve CD4+ T cells to produce Th2 cytokines. In addition, to low production of Th2 cytokines, strong Th1 response, which plays an important role in vitiligo development, has been induced by blockade of TSLP or TSLP receptor. This study examined whether a functional TSLP polymorphism was associated with vitiligo. One hundred and sixty Korean patients with vitiligo and 568 healthy Korean individuals were examined for the four SNPs of TSLP gene. Luciferase activity was measured for promoter assay. The genotype and allele frequencies of −847C>T polymorphism were lower in vitiligo patients compared with the controls, whereas those of wild type were higher (P = 0.004, P = 0.017 respectively). None the less, the promoter activity of −847C decreased significantly (P = 0.013) compared with −847T, expecting lower TSLP mRNA levels in the polymorphism. Collectively, C allele at the TSLP −847C>T polymorphism may increase susceptibility to generalized vitiligo through decreasing TSLP mRNA expression levels.