A novel pseudo four component reaction involving homoenolate for the synthesis of gamma-aminobutyric acid (GABA) derivatives

A novel pseudo four component reaction involving homoenolate for the synthesis of gamma-aminobutyric acid (GABA) derivatives

Homoenolate generated from alpha,beta-unsaturated aldehydes by NHC catalysis underwent facile addition to conjugated sulfonimines, generated in situ, and subsequent methanolysis to afford protected GABA derivatives stereoselectively and in high yields, thus constituting a novel pseudo four component...

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Veröffentlicht in:Organic & biomolecular chemistry 2010-01, Vol.8 (4), p.761-764
Hauptverfasser: Nair, Vijay, Varghese, Vimal, Babu, Beneesh P, Sinu, C R, Suresh, Eringathodi
Format: Artikel
Sprache:eng
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Zusammenfassung:Homoenolate generated from alpha,beta-unsaturated aldehydes by NHC catalysis underwent facile addition to conjugated sulfonimines, generated in situ, and subsequent methanolysis to afford protected GABA derivatives stereoselectively and in high yields, thus constituting a novel pseudo four component reaction.
ISSN:1477-0520
1477-0539
DOI:10.1039/b922981g