The Effect of Cytomegalovirus Antigenemia Titer on the Efficacy of Preemptive Therapy for the Prevention of Cytomegalovirus Disease After Kidney Transplantation

The Effect of Cytomegalovirus Antigenemia Titer on the Efficacy of Preemptive Therapy for the Prevention of Cytomegalovirus Disease After Kidney Transplantation

Abstract There is some controversy regarding the exact cytomegalovirus (CMV) antigenemia titer that should be used as a guideline for preemptive anti-CMV therapy. We performed 634 consecutive kidney transplantations between January 2000 and June 2007. Preemptive therapy employed intravenous gancyclo...

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Veröffentlicht in:Transplantation proceedings 2010-04, Vol.42 (3), p.804-810
Hauptverfasser: Jung, G.O, Kim, S.-J, Choi, G.-S, Moon, J.I, Kim, J.M, Sin, M.J, Kim, E.Y, Kwon, C.H.D, Joh, J.W, Lee, S.-K
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Analysis of Variance
Antigens, Viral - blood
Antiviral Agents - therapeutic use
Biological and medical sciences
Cadaver
Chi-Square Distribution
Cytomegalovirus Infections - diagnosis
Cytomegalovirus Infections - drug therapy
Cytomegalovirus Infections - epidemiology
Cytomegalovirus Infections - prevention & control
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Graft Rejection - immunology
Graft Rejection - prevention & control
Humans
Immunosuppressive Agents - therapeutic use
Infectious diseases
Kidney Transplantation - adverse effects
Kidney Transplantation - immunology
Living Donors
Male
Medical sciences
Middle Aged
Postoperative Complications - drug therapy
Postoperative Complications - epidemiology
Postoperative Complications - prevention & control
Postoperative Complications - virology
Retrospective Studies
Risk Factors
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Tissue Donors
Tissue, organ and graft immunology
Viral diseases
Young Adult
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Zusammenfassung:Abstract There is some controversy regarding the exact cytomegalovirus (CMV) antigenemia titer that should be used as a guideline for preemptive anti-CMV therapy. We performed 634 consecutive kidney transplantations between January 2000 and June 2007. Preemptive therapy employed intravenous gancyclovir treatment when the CMV antigenemia titer was ≥50/4 × 105 leukocytes after kidney transplantation. The 634 recipients were allocated into 2 groups according to the peak CMV antegenemia: group A, CMV antigenemia titer
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2010.02.040