Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines

Two series of analogues of the marine pyrroloiminoquinone alkaloids tsitsikammamine have been synthesized on the basis of a Michael addition between 2′-amino-1-(4-methoxyphenyl)-ethanol and two indolediones. All the compounds were evaluated in vitro for antiproliferative activity against distinct ca...

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Veröffentlicht in:	European journal of medicinal chemistry 2010, Vol.45 (1), p.343-351
Hauptverfasser:	Rives, Arnaud, Le Calvé, Benjamin, Delaine, Tamara, Legentil, Laurent, Kiss, Robert, Delfourne, Evelyne
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor activity Biological and medical sciences Cell Line, Tumor Cell Proliferation - drug effects General aspects Humans Inhibitory Concentration 50 Marine alkaloid Medical sciences Oceans and Seas Pharmacology. Drug treatments Pyrroloiminoquinone Quinolines - chemical synthesis Quinolines - chemistry Quinolines - pharmacology Tsitsikammamine
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Beschreibung
Zusammenfassung:	Two series of analogues of the marine pyrroloiminoquinone alkaloids tsitsikammamine have been synthesized on the basis of a Michael addition between 2′-amino-1-(4-methoxyphenyl)-ethanol and two indolediones. All the compounds were evaluated in vitro for antiproliferative activity against distinct cancer cell lines. [Display omitted]
ISSN:	0223-5234 1768-3254
DOI:	10.1016/j.ejmech.2009.10.019