Activation of JNK signaling links lgl mutations to disruption of the cell polarity and epithelial organization in Drosophila imaginal discs
Dear Editor, Identification of Drosophila melanogaster as a model organism for cancer research has facilitated the exploration of human tumor malignancy. In Drosophila, loss- of-function mutations in the neoplastic tumor suppressor genes （nYSGs） lethal（2）giant larvae （lgl）, discs large （dlg） or scri...
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| Veröffentlicht in: | Cell research 2010-02, Vol.20 (2), p.242-245 |
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| creator | Zhu, Mingwei Xin, Tianchi Weng, Shunyan Gao, Yin Zhang, Yingjie Li, Qi Li, Mingfa |
| description | Dear Editor,
Identification of Drosophila melanogaster as a model organism for cancer research has facilitated the exploration of human tumor malignancy. In Drosophila, loss- of-function mutations in the neoplastic tumor suppressor genes （nYSGs） lethal（2）giant larvae （lgl）, discs large （dlg） or scribble （scrib） cause a malignant tumor-like phenotype characteristic of disrupted cell polarity and overgrowth in epithelial tissues such as imaginal discs [1 ]. |
| doi_str_mv | 10.1038/cr.2010.2 |
| format | Article |
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Identification of Drosophila melanogaster as a model organism for cancer research has facilitated the exploration of human tumor malignancy. In Drosophila, loss- of-function mutations in the neoplastic tumor suppressor genes （nYSGs） lethal（2）giant larvae （lgl）, discs large （dlg） or scribble （scrib） cause a malignant tumor-like phenotype characteristic of disrupted cell polarity and overgrowth in epithelial tissues such as imaginal discs [1 ].</description><identifier>ISSN: 1001-0602</identifier><identifier>EISSN: 1748-7838</identifier><identifier>DOI: 10.1038/cr.2010.2</identifier><identifier>PMID: 20066009</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/136/1425 ; 631/67 ; 631/80/85 ; 631/80/86 ; Animals ; Animals, Genetically Modified ; Biomedical and Life Sciences ; Blastodisc - embryology ; Blastodisc - metabolism ; Blastodisc - ultrastructure ; Body Patterning - genetics ; Body Patterning - physiology ; Cell Biology ; Cell Polarity - genetics ; Drosophila melanogaster - embryology ; Drosophila melanogaster - genetics ; Drosophila melanogaster - metabolism ; Drosophila Proteins - genetics ; Drosophila Proteins - physiology ; Embryo, Nonmammalian ; Enzyme Activation - physiology ; Epithelium - embryology ; Epithelium - ultrastructure ; Genetic Linkage - physiology ; JNK ; JNK Mitogen-Activated Protein Kinases - metabolism ; JNK Mitogen-Activated Protein Kinases - physiology ; letter-to-the-editor ; Life Sciences ; Models, Biological ; Mutation - physiology ; Signal Transduction - genetics ; Signal Transduction - physiology ; Tumor Suppressor Proteins - genetics ; Tumor Suppressor Proteins - physiology ; 上皮组织 ; 信令链路 ; 细胞极性</subject><ispartof>Cell research, 2010-02, Vol.20 (2), p.242-245</ispartof><rights>Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2010</rights><rights>Copyright Nature Publishing Group Feb 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-a4a11d700c7c6f2f49491fca6dc4c3fe8a25da99fcea06f507c3c952f0d38793</citedby><cites>FETCH-LOGICAL-c409t-a4a11d700c7c6f2f49491fca6dc4c3fe8a25da99fcea06f507c3c952f0d38793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85240X/85240X.jpg</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/cr.2010.2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/cr.2010.2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20066009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Mingwei</creatorcontrib><creatorcontrib>Xin, Tianchi</creatorcontrib><creatorcontrib>Weng, Shunyan</creatorcontrib><creatorcontrib>Gao, Yin</creatorcontrib><creatorcontrib>Zhang, Yingjie</creatorcontrib><creatorcontrib>Li, Qi</creatorcontrib><creatorcontrib>Li, Mingfa</creatorcontrib><title>Activation of JNK signaling links lgl mutations to disruption of the cell polarity and epithelial organization in Drosophila imaginal discs</title><title>Cell research</title><addtitle>Cell Res</addtitle><addtitle>Cell Research</addtitle><description>Dear Editor,
Identification of Drosophila melanogaster as a model organism for cancer research has facilitated the exploration of human tumor malignancy. In Drosophila, loss- of-function mutations in the neoplastic tumor suppressor genes （nYSGs） lethal（2）giant larvae （lgl）, discs large （dlg） or scribble （scrib） cause a malignant tumor-like phenotype characteristic of disrupted cell polarity and overgrowth in epithelial tissues such as imaginal discs [1 ].</description><subject>631/136/1425</subject><subject>631/67</subject><subject>631/80/85</subject><subject>631/80/86</subject><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>Biomedical and Life Sciences</subject><subject>Blastodisc - embryology</subject><subject>Blastodisc - metabolism</subject><subject>Blastodisc - ultrastructure</subject><subject>Body Patterning - genetics</subject><subject>Body Patterning - physiology</subject><subject>Cell Biology</subject><subject>Cell Polarity - genetics</subject><subject>Drosophila melanogaster - embryology</subject><subject>Drosophila melanogaster - genetics</subject><subject>Drosophila melanogaster - metabolism</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - physiology</subject><subject>Embryo, Nonmammalian</subject><subject>Enzyme Activation - physiology</subject><subject>Epithelium - embryology</subject><subject>Epithelium - ultrastructure</subject><subject>Genetic Linkage - physiology</subject><subject>JNK</subject><subject>JNK Mitogen-Activated Protein Kinases - metabolism</subject><subject>JNK Mitogen-Activated Protein Kinases - physiology</subject><subject>letter-to-the-editor</subject><subject>Life Sciences</subject><subject>Models, Biological</subject><subject>Mutation - physiology</subject><subject>Signal Transduction - genetics</subject><subject>Signal Transduction - physiology</subject><subject>Tumor Suppressor Proteins - genetics</subject><subject>Tumor Suppressor Proteins - physiology</subject><subject>上皮组织</subject><subject>信令链路</subject><subject>细胞极性</subject><issn>1001-0602</issn><issn>1748-7838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkU1vFSEYhYmxsR-68A8YogujydQXmBlg2VRtq41uuieUgbm0XJjCjEn9C_3Tcr23xuiGj7wP53ByEHpJ4JgAEx9MPqZQL_QJOiC8FQ0XTDytZwDSQA90Hx2WcgNAu7Yjz9A-Beh7AHmAHk7M7H_o2aeIk8Nfvn3FxY9RBx9HXJfbgsMY8HqZfzMFzwkPvuRlenwyryw2NgQ8paCzn--xjgO2k6-D4HXAKY86-p9bDx_xx5xKmlY-aOzXevTVbCNpynO053Qo9sVuP0JXnz9dnZ43l9_PLk5PLhvTgpwb3WpCBg5guOkdda1sJXFG94NpDXNWaNoNWkpnrIbedcANM7KjDgYmuGRH6O1WdsrpbrFlVuvqXhPoaNNSFGdM0l5QXsk3_5A3acn1v0URoJwCFZRV6t2WMjVYydapKddg-b5CatOPMllt-lG0sq92isv12g5_yMdCKvB-C5Q6iqPNf1v-r_Z657xKcbyrvLrW5tb5YBVjIIgkhP0Cpnqmiw</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Zhu, Mingwei</creator><creator>Xin, Tianchi</creator><creator>Weng, Shunyan</creator><creator>Gao, Yin</creator><creator>Zhang, Yingjie</creator><creator>Li, Qi</creator><creator>Li, Mingfa</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W94</scope><scope>WU4</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20100201</creationdate><title>Activation of JNK signaling links lgl mutations to disruption of the cell polarity and epithelial organization in Drosophila imaginal discs</title><author>Zhu, Mingwei ; Xin, Tianchi ; Weng, Shunyan ; Gao, Yin ; Zhang, Yingjie ; Li, Qi ; Li, Mingfa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-a4a11d700c7c6f2f49491fca6dc4c3fe8a25da99fcea06f507c3c952f0d38793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>631/136/1425</topic><topic>631/67</topic><topic>631/80/85</topic><topic>631/80/86</topic><topic>Animals</topic><topic>Animals, Genetically Modified</topic><topic>Biomedical and Life Sciences</topic><topic>Blastodisc - 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Academic</collection><jtitle>Cell research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Mingwei</au><au>Xin, Tianchi</au><au>Weng, Shunyan</au><au>Gao, Yin</au><au>Zhang, Yingjie</au><au>Li, Qi</au><au>Li, Mingfa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of JNK signaling links lgl mutations to disruption of the cell polarity and epithelial organization in Drosophila imaginal discs</atitle><jtitle>Cell research</jtitle><stitle>Cell Res</stitle><addtitle>Cell Research</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>20</volume><issue>2</issue><spage>242</spage><epage>245</epage><pages>242-245</pages><issn>1001-0602</issn><eissn>1748-7838</eissn><abstract>Dear Editor,
Identification of Drosophila melanogaster as a model organism for cancer research has facilitated the exploration of human tumor malignancy. In Drosophila, loss- of-function mutations in the neoplastic tumor suppressor genes （nYSGs） lethal（2）giant larvae （lgl）, discs large （dlg） or scribble （scrib） cause a malignant tumor-like phenotype characteristic of disrupted cell polarity and overgrowth in epithelial tissues such as imaginal discs [1 ].</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>20066009</pmid><doi>10.1038/cr.2010.2</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cell research, 2010-02, Vol.20 (2), p.242-245 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | 631/136/1425 631/67 631/80/85 631/80/86 Animals Animals, Genetically Modified Biomedical and Life Sciences Blastodisc - embryology Blastodisc - metabolism Blastodisc - ultrastructure Body Patterning - genetics Body Patterning - physiology Cell Biology Cell Polarity - genetics Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - physiology Embryo, Nonmammalian Enzyme Activation - physiology Epithelium - embryology Epithelium - ultrastructure Genetic Linkage - physiology JNK JNK Mitogen-Activated Protein Kinases - metabolism JNK Mitogen-Activated Protein Kinases - physiology letter-to-the-editor Life Sciences Models, Biological Mutation - physiology Signal Transduction - genetics Signal Transduction - physiology Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - physiology 上皮组织 信令链路 细胞极性 |
| title | Activation of JNK signaling links lgl mutations to disruption of the cell polarity and epithelial organization in Drosophila imaginal discs |
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