Activation of JNK signaling links lgl mutations to disruption of the cell polarity and epithelial organization in Drosophila imaginal discs

Dear Editor, Identification of Drosophila melanogaster as a model organism for cancer research has facilitated the exploration of human tumor malignancy. In Drosophila, loss- of-function mutations in the neoplastic tumor suppressor genes （nYSGs） lethal（2）giant larvae （lgl）, discs large （dlg） or scribble （scrib） cause a malignant tumor-like phenotype characteristic of disrupted cell polarity and overgrowth in epithelial tissues such as imaginal discs [1 ].