Molecular iodine promoted synthesis of new pyrazolo[3,4-d]pyrimidine derivatives as potential antibacterial agents

Iodocyclization of 5-amino-1-(2,4-dinitrophenyl)-1H-4-pyrazolcarboxamides with aromatic aldehydes gave a new series of pyrazolo[3,4-d]pyrimidine derivatives in a single step and their antibacterial activity comparable to Streptomycin as reference drug was evaluated.

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Bibliographische Detailangaben
Veröffentlicht in:	European journal of medicinal chemistry 2010-02, Vol.45 (2), p.647-650
Hauptverfasser:	BAKAVOLI, Mehdi, BAGHERZADEH, Ghodsieh, VASEGHIFAR, Maryam, SHIRI, Ali, PORDEL, Mehdi, MASHREGHI, Mansour, PORDELI, Parvaneh, ARAGHI, Maryam
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria - drug effects Biological and medical sciences Catalysis Cyclization Iodine - chemistry Medical sciences Oxidation-Reduction Pharmacology. Drug treatments Pyrimidines - chemical synthesis Pyrimidines - chemistry Pyrimidines - pharmacology
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Beschreibung
Zusammenfassung:	Iodocyclization of 5-amino-1-(2,4-dinitrophenyl)-1H-4-pyrazolcarboxamides with aromatic aldehydes gave a new series of pyrazolo[3,4-d]pyrimidine derivatives in a single step and their antibacterial activity comparable to Streptomycin as reference drug was evaluated.
ISSN:	0223-5234 1768-3254
DOI:	10.1016/j.ejmech.2009.10.051