Down's syndrome in diabetic patients aged <20 years: an analysis of metabolic status, glycaemic control and autoimmunity in comparison with type 1 diabetes

Down's syndrome in diabetic patients aged <20 years: an analysis of metabolic status, glycaemic control and autoimmunity in comparison with type 1 diabetes

Aims/hypothesis Intellectual impairment in individuals with Down's syndrome and diabetes mellitus potentially limits the quality of diabetic control. In addition, these patients are at risk of having immunological abnormalities. The present study compared metabolic status and concomitant diseas...

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Veröffentlicht in:Diabetologia 2010-06, Vol.53 (6), p.1070-1075
Hauptverfasser: Rohrer, T. R, Hennes, P, Thon, A, Dost, A, Grabert, M, Rami, B, Wiegand, S, Holl, R. W
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Age Distribution
Age of Onset
Autoantibodies - immunology
Autoimmunity - immunology
Beta cell autoantibodies
Biological and medical sciences
Blood Glucose - metabolism
Child
Chromosome aberrations
Coeliac antibodies
Databases, Factual
diabetes mellitus
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - immunology
Diabetes Mellitus, Type 1 - metabolism
Diabetes Mellitus, Type 1 - therapy
Diabetes. Impaired glucose tolerance
Down syndrome
Down Syndrome - complications
Down Syndrome - immunology
Down Syndrome - metabolism
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Haemoglobin A₁c
Human Physiology
Humans
Hypoglycemic Agents - therapeutic use
insulin
Insulin - therapeutic use
Internal Medicine
Islet autoantibodies
Male
Medical genetics
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
metabolism
Regression Analysis
Thyroid
Trisomy 21
Young Adult
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Zusammenfassung:Aims/hypothesis Intellectual impairment in individuals with Down's syndrome and diabetes mellitus potentially limits the quality of diabetic control. In addition, these patients are at risk of having immunological abnormalities. The present study compared metabolic status and concomitant diseases in young (
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-010-1686-z