Genome-wide association study of panic disorder in the Japanese population

Panic disorder (PD) is an anxiety disorder characterized by panic attacks and anticipatory anxiety. Although a number of association studies have been conducted, no gene has been identified as a susceptibility locus. In this study, we conducted a genome-wide association study of PD in 200 Japanese patients and the same number of controls, using the GeneChip Human Mapping 500 K Array Set. Genotypes were determined using the Bayesian Robust Linear Model with Mahalanobis (BRLMM) genotype calling algorithm. The genotype data were data-cleaned using criteria for SNP call rate (⩾95%), Hardy–Weinberg equilibrium ( P ⩾0.1%) and minor allele frequency (⩾5%). The significance level of the allele P -value was set at 1.0 × 10 −6 , to make false discovery rate (FDR)