Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol

Resveratrol increases longevity through SirT1, which is activated with NAD(+) supplied by an anti-aging enzyme PBEF. SirT1 interacts with an anti-aging transcription factor, FoxO1, which is negatively regulated by Akt. Since white wine could have similar health benefits as red wine, we determined if...

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Veröffentlicht in:	Free radical biology & medicine 2009-03, Vol.46 (5), p.573-578
Hauptverfasser:	Mukherjee, Subhendu, Lekli, Istvan, Gurusamy, Narasimman, Bertelli, Alberto A A, Das, Dipak K
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Apoptosis - drug effects Cardiotonic Agents - administration & dosage Cardiotonic Agents - chemistry Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism In Situ Nick-End Labeling Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nicotinamide Phosphoribosyltransferase - genetics Nicotinamide Phosphoribosyltransferase - metabolism Oncogene Protein v-akt - genetics Oncogene Protein v-akt - metabolism Phenylethyl Alcohol - administration & dosage Phenylethyl Alcohol - analogs & derivatives Phenylethyl Alcohol - chemistry Rats Rats, Sprague-Dawley Reperfusion Injury - metabolism Reperfusion Injury - pathology Reperfusion Injury - prevention & control Signal Transduction Sirtuins - genetics Sirtuins - metabolism Stilbenes - administration & dosage Stilbenes - chemistry Transcriptional Activation Vitaceae Wine
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