Study of Phosphatidylserine-dependent Anti-prothrombin Antibody in Cerebral Infarction

Purpose This study was carried out to clarify the relationship of IgG phosphatidylserine-dependent anti-prothrombin antibody (aPS/PT), IgG beta 2 glycoprotein I-dependent anticardiolipin antibody (beta 2-GPI aCL), and lupus anticoagulant (LA) to cerebral infarction, using data from 93 patients who visited our hospitals. Materials and Methods We computed the positive rates for each of IgG aPS/PT, beta 2-GPI aCL, and LA in the 93 patients with cerebral infarction, and carried out logistic regression analysis with IgG aPS/PT as the outcome variable and with beta 2-GPI aCL, LA, and each risk factor as predictor variables in order to assess the relationship of IgG aPS/PT with each factor. Results IgG aPS/PT was more highly correlated with LA than beta 2-GPI aCL in IgG aPS/PT-positive patients with cerebral infarction. IgG aPS/PT itself appears to have high specificity as a marker for antiphospholipid syndrome (APS), because there were patients who were IgG aPS/PT-positive but both beta 2-GPI aCL- and LA-negative. Conclusion In IgG aPS/PT-positive patients with cerebral infarction, IgG aPS/PT is more highly correlated with LA than beta 2-GPI aCL. It is also strongly associated with APS. Measurement of IgG aPS/PT in patients with cerebral infarction could be of diagnostic value.