BACE1 (Beta-Secretase) Inhibitory Phenolic Acids and a Novel Sesquiterpenoid from Homalomena occulta

Four phenolic acids, namely 2‐[(Z)‐heptadec‐11‐enyl]‐6‐hydroxybenzoic acid (1), 2‐[(6Z,9Z,12Z)‐heptadeca‐6,9,12‐trienyl]‐6‐hydroxybenzoic acid (2), 2‐[(9Z,12Z)‐heptadeca‐9,12‐dienyl]‐6‐hydroxybenzoic acid (3), and 2‐hydroxy‐6‐(12‐phenyldodecyl)benzoic acid (4), and one sesquiterpene, asperpenoid (5), were isolated from the 95% EtOH extract of the roots of Homalomena occulta, among which 1, 2, and 5 represent new compounds. Further, the phenolic acids 1–4 exhibited BACE1 (β‐secretase) inhibitory activity with IC50 values of 6.23±0.94, 6.28±0.63, 7.93±0.38, and 7.65±0.62 μM, respectively.