Acute bronchodilator responsiveness in subjects with and without airflow obstruction in five Latin American cities: The PLATINO study
Abstract Background Acute bronchodilator responsiveness is an area of discussion in COPD. No information exists regarding this aspect of the disease from an unselected COPD population. We assessed acute bronchodilator responsiveness and factors influencing it in subjects with and without airway obst...
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| Veröffentlicht in: | Pulmonary pharmacology & therapeutics 2010-02, Vol.23 (1), p.29-35 |
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| creator | Montes de Oca, Maria Perez-Padilla, Rogelio Tálamo, Carlos Halbert, Ronald J Moreno, Dolores Lopez, Maria Victorina Muiño, Adriana José Roberto, B. Jardim Valdivia, Gonzalo Pertuzé, Julio Ana Maria, B. Menezes |
| description | Abstract Background Acute bronchodilator responsiveness is an area of discussion in COPD. No information exists regarding this aspect of the disease from an unselected COPD population. We assessed acute bronchodilator responsiveness and factors influencing it in subjects with and without airway obstruction in an epidemiologic sample. Methods COPD was defined by GOLD criteria (post-bronchodilator FEV1 /FVC < 0.70). In this analysis, subjects with pre-bronchodilator FEV1 /FVC |
| doi_str_mv | 10.1016/j.pupt.2009.09.005 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733899745</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1094553909001060</els_id><sourcerecordid>733899745</sourcerecordid><originalsourceid>FETCH-LOGICAL-c410t-f6ff63e42797d092a3e73f3e3a1c3fbf7e6ab47eb58e7f99e4a1099acc9680f03</originalsourceid><addsrcrecordid>eNp9kVuLFDEQhRtR3HX1D_ggefOpZyudvkVEGBYvC4MrOD6HdLrCZOxJ2lx2mR_g_zbtDCz4IBTUeTjnQH1VFK8prCjQ9nq_mtMcVxUAXy0DzZPikjZVVfK24k-zBl6XTcP4RfEihD0AdDVrnhcXlPe079vusvi9VikiGbyzaudGM8noPPEYZmeDuUeLIRBjSUjDHlUM5MHEHZF2_CtcikQaryf3QNwQok8qGmeXgM5hspExy_UBvVHSEmWiwfCObHdIvm3W29uvdyTENB5fFs-0nAK-Ou-r4senj9ubL-Xm7vPtzXpTqppCLHWrdcuwrjrejcArybBjmiGTVDE96A5bOdQdDk2PneYca5kRcKkUb3vQwK6Kt6fe2btfCUMUBxMUTpO06FIQHWM9513dZGd1cirvQvCoxezNQfqjoCAW-mIvFvpioS-WgSX05lyfhgOOj5Ez7mx4fzJgPvLeoBdBGbQKR-MzXTE68__-D__E1WRsRjv9xCOGvUveZnyCilAJEN-X_y_vBw5AoQX2B7u3rk0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733899745</pqid></control><display><type>article</type><title>Acute bronchodilator responsiveness in subjects with and without airflow obstruction in five Latin American cities: The PLATINO study</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Montes de Oca, Maria ; Perez-Padilla, Rogelio ; Tálamo, Carlos ; Halbert, Ronald J ; Moreno, Dolores ; Lopez, Maria Victorina ; Muiño, Adriana ; José Roberto, B. Jardim ; Valdivia, Gonzalo ; Pertuzé, Julio ; Ana Maria, B. Menezes</creator><creatorcontrib>Montes de Oca, Maria ; Perez-Padilla, Rogelio ; Tálamo, Carlos ; Halbert, Ronald J ; Moreno, Dolores ; Lopez, Maria Victorina ; Muiño, Adriana ; José Roberto, B. Jardim ; Valdivia, Gonzalo ; Pertuzé, Julio ; Ana Maria, B. Menezes ; For the PLATINO Team ; PLATINO Team</creatorcontrib><description>Abstract Background Acute bronchodilator responsiveness is an area of discussion in COPD. No information exists regarding this aspect of the disease from an unselected COPD population. We assessed acute bronchodilator responsiveness and factors influencing it in subjects with and without airway obstruction in an epidemiologic sample. Methods COPD was defined by GOLD criteria (post-bronchodilator FEV1 /FVC < 0.70). In this analysis, subjects with pre-bronchodilator FEV1 /FVC <0.70 but ≥0.70 post-bronchodilator were considered to have reversible obstruction. Bronchodilator responsiveness after albuterol 200 μg was assessed using three definitions: a) FVC and/or FEV1 increment ≥12% plus ≥200 mL over baseline; b) FEV1 ≥ 15% increase over baseline; and c) FEV1 increase ≥10% of predicted value. Results There were 756 healthy respiratory subjects, 481 subjects with reversible obstruction and 759 COPD subjects. Depending on the criterion used the proportion of person with acute bronchodilator responsiveness ranged between 15.0–28.2% in COPD, 11.4–21.6% in reversible obstructed and 2.7–7.2% in respiratory healthy. FEV1 changes were lower (110.6 ± 7.40 vs. 164.7 ± 11.8 mL) and FVC higher (146.5 ± 14.2 mL vs. −131.0 ± 19.6 mL) in COPD subjects compared with reversible obstructed. Substantial overlap in FEV1 and FVC changes was observed among the groups. Acute bronchodilator responsiveness in COPD persons was associated with less obstruction and never smoking. Conclusions Over two-thirds of persons with COPD did not demonstrate acute bronchodilator responsiveness. The overall response was small and less than that considered as significant by ATS criteria. The overlap in FEV1 and FVC changes after bronchodilator among the groups makes it difficult to determine a threshold for separating them.</description><identifier>ISSN: 1094-5539</identifier><identifier>EISSN: 1522-9629</identifier><identifier>DOI: 10.1016/j.pupt.2009.09.005</identifier><identifier>PMID: 19818867</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Aged ; Bronchi - physiopathology ; Bronchodilator ; Chronic obstructive pulmonary disease ; Epidemiology asthma/COPD ; Female ; Forced Expiratory Volume ; Humans ; Male ; Medical Education ; Middle Aged ; Multivariate Analysis ; Prevalence ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary/Respiratory</subject><ispartof>Pulmonary pharmacology & therapeutics, 2010-02, Vol.23 (1), p.29-35</ispartof><rights>Elsevier Ltd</rights><rights>2009 Elsevier Ltd</rights><rights>Copyright 2009 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-f6ff63e42797d092a3e73f3e3a1c3fbf7e6ab47eb58e7f99e4a1099acc9680f03</citedby><cites>FETCH-LOGICAL-c410t-f6ff63e42797d092a3e73f3e3a1c3fbf7e6ab47eb58e7f99e4a1099acc9680f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1094553909001060$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19818867$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Montes de Oca, Maria</creatorcontrib><creatorcontrib>Perez-Padilla, Rogelio</creatorcontrib><creatorcontrib>Tálamo, Carlos</creatorcontrib><creatorcontrib>Halbert, Ronald J</creatorcontrib><creatorcontrib>Moreno, Dolores</creatorcontrib><creatorcontrib>Lopez, Maria Victorina</creatorcontrib><creatorcontrib>Muiño, Adriana</creatorcontrib><creatorcontrib>José Roberto, B. Jardim</creatorcontrib><creatorcontrib>Valdivia, Gonzalo</creatorcontrib><creatorcontrib>Pertuzé, Julio</creatorcontrib><creatorcontrib>Ana Maria, B. Menezes</creatorcontrib><creatorcontrib>For the PLATINO Team</creatorcontrib><creatorcontrib>PLATINO Team</creatorcontrib><title>Acute bronchodilator responsiveness in subjects with and without airflow obstruction in five Latin American cities: The PLATINO study</title><title>Pulmonary pharmacology & therapeutics</title><addtitle>Pulm Pharmacol Ther</addtitle><description>Abstract Background Acute bronchodilator responsiveness is an area of discussion in COPD. No information exists regarding this aspect of the disease from an unselected COPD population. We assessed acute bronchodilator responsiveness and factors influencing it in subjects with and without airway obstruction in an epidemiologic sample. Methods COPD was defined by GOLD criteria (post-bronchodilator FEV1 /FVC < 0.70). In this analysis, subjects with pre-bronchodilator FEV1 /FVC <0.70 but ≥0.70 post-bronchodilator were considered to have reversible obstruction. Bronchodilator responsiveness after albuterol 200 μg was assessed using three definitions: a) FVC and/or FEV1 increment ≥12% plus ≥200 mL over baseline; b) FEV1 ≥ 15% increase over baseline; and c) FEV1 increase ≥10% of predicted value. Results There were 756 healthy respiratory subjects, 481 subjects with reversible obstruction and 759 COPD subjects. Depending on the criterion used the proportion of person with acute bronchodilator responsiveness ranged between 15.0–28.2% in COPD, 11.4–21.6% in reversible obstructed and 2.7–7.2% in respiratory healthy. FEV1 changes were lower (110.6 ± 7.40 vs. 164.7 ± 11.8 mL) and FVC higher (146.5 ± 14.2 mL vs. −131.0 ± 19.6 mL) in COPD subjects compared with reversible obstructed. Substantial overlap in FEV1 and FVC changes was observed among the groups. Acute bronchodilator responsiveness in COPD persons was associated with less obstruction and never smoking. Conclusions Over two-thirds of persons with COPD did not demonstrate acute bronchodilator responsiveness. The overall response was small and less than that considered as significant by ATS criteria. The overlap in FEV1 and FVC changes after bronchodilator among the groups makes it difficult to determine a threshold for separating them.</description><subject>Aged</subject><subject>Bronchi - physiopathology</subject><subject>Bronchodilator</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Epidemiology asthma/COPD</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Humans</subject><subject>Male</subject><subject>Medical Education</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Prevalence</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Pulmonary/Respiratory</subject><issn>1094-5539</issn><issn>1522-9629</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVuLFDEQhRtR3HX1D_ggefOpZyudvkVEGBYvC4MrOD6HdLrCZOxJ2lx2mR_g_zbtDCz4IBTUeTjnQH1VFK8prCjQ9nq_mtMcVxUAXy0DzZPikjZVVfK24k-zBl6XTcP4RfEihD0AdDVrnhcXlPe079vusvi9VikiGbyzaudGM8noPPEYZmeDuUeLIRBjSUjDHlUM5MHEHZF2_CtcikQaryf3QNwQok8qGmeXgM5hspExy_UBvVHSEmWiwfCObHdIvm3W29uvdyTENB5fFs-0nAK-Ou-r4senj9ubL-Xm7vPtzXpTqppCLHWrdcuwrjrejcArybBjmiGTVDE96A5bOdQdDk2PneYca5kRcKkUb3vQwK6Kt6fe2btfCUMUBxMUTpO06FIQHWM9513dZGd1cirvQvCoxezNQfqjoCAW-mIvFvpioS-WgSX05lyfhgOOj5Ez7mx4fzJgPvLeoBdBGbQKR-MzXTE68__-D__E1WRsRjv9xCOGvUveZnyCilAJEN-X_y_vBw5AoQX2B7u3rk0</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Montes de Oca, Maria</creator><creator>Perez-Padilla, Rogelio</creator><creator>Tálamo, Carlos</creator><creator>Halbert, Ronald J</creator><creator>Moreno, Dolores</creator><creator>Lopez, Maria Victorina</creator><creator>Muiño, Adriana</creator><creator>José Roberto, B. Jardim</creator><creator>Valdivia, Gonzalo</creator><creator>Pertuzé, Julio</creator><creator>Ana Maria, B. Menezes</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100201</creationdate><title>Acute bronchodilator responsiveness in subjects with and without airflow obstruction in five Latin American cities: The PLATINO study</title><author>Montes de Oca, Maria ; Perez-Padilla, Rogelio ; Tálamo, Carlos ; Halbert, Ronald J ; Moreno, Dolores ; Lopez, Maria Victorina ; Muiño, Adriana ; José Roberto, B. Jardim ; Valdivia, Gonzalo ; Pertuzé, Julio ; Ana Maria, B. Menezes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-f6ff63e42797d092a3e73f3e3a1c3fbf7e6ab47eb58e7f99e4a1099acc9680f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Bronchi - physiopathology</topic><topic>Bronchodilator</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Epidemiology asthma/COPD</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Humans</topic><topic>Male</topic><topic>Medical Education</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Prevalence</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Pulmonary/Respiratory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Montes de Oca, Maria</creatorcontrib><creatorcontrib>Perez-Padilla, Rogelio</creatorcontrib><creatorcontrib>Tálamo, Carlos</creatorcontrib><creatorcontrib>Halbert, Ronald J</creatorcontrib><creatorcontrib>Moreno, Dolores</creatorcontrib><creatorcontrib>Lopez, Maria Victorina</creatorcontrib><creatorcontrib>Muiño, Adriana</creatorcontrib><creatorcontrib>José Roberto, B. Jardim</creatorcontrib><creatorcontrib>Valdivia, Gonzalo</creatorcontrib><creatorcontrib>Pertuzé, Julio</creatorcontrib><creatorcontrib>Ana Maria, B. Menezes</creatorcontrib><creatorcontrib>For the PLATINO Team</creatorcontrib><creatorcontrib>PLATINO Team</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pulmonary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Montes de Oca, Maria</au><au>Perez-Padilla, Rogelio</au><au>Tálamo, Carlos</au><au>Halbert, Ronald J</au><au>Moreno, Dolores</au><au>Lopez, Maria Victorina</au><au>Muiño, Adriana</au><au>José Roberto, B. Jardim</au><au>Valdivia, Gonzalo</au><au>Pertuzé, Julio</au><au>Ana Maria, B. Menezes</au><aucorp>For the PLATINO Team</aucorp><aucorp>PLATINO Team</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute bronchodilator responsiveness in subjects with and without airflow obstruction in five Latin American cities: The PLATINO study</atitle><jtitle>Pulmonary pharmacology & therapeutics</jtitle><addtitle>Pulm Pharmacol Ther</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>23</volume><issue>1</issue><spage>29</spage><epage>35</epage><pages>29-35</pages><issn>1094-5539</issn><eissn>1522-9629</eissn><abstract>Abstract Background Acute bronchodilator responsiveness is an area of discussion in COPD. No information exists regarding this aspect of the disease from an unselected COPD population. We assessed acute bronchodilator responsiveness and factors influencing it in subjects with and without airway obstruction in an epidemiologic sample. Methods COPD was defined by GOLD criteria (post-bronchodilator FEV1 /FVC < 0.70). In this analysis, subjects with pre-bronchodilator FEV1 /FVC <0.70 but ≥0.70 post-bronchodilator were considered to have reversible obstruction. Bronchodilator responsiveness after albuterol 200 μg was assessed using three definitions: a) FVC and/or FEV1 increment ≥12% plus ≥200 mL over baseline; b) FEV1 ≥ 15% increase over baseline; and c) FEV1 increase ≥10% of predicted value. Results There were 756 healthy respiratory subjects, 481 subjects with reversible obstruction and 759 COPD subjects. Depending on the criterion used the proportion of person with acute bronchodilator responsiveness ranged between 15.0–28.2% in COPD, 11.4–21.6% in reversible obstructed and 2.7–7.2% in respiratory healthy. FEV1 changes were lower (110.6 ± 7.40 vs. 164.7 ± 11.8 mL) and FVC higher (146.5 ± 14.2 mL vs. −131.0 ± 19.6 mL) in COPD subjects compared with reversible obstructed. Substantial overlap in FEV1 and FVC changes was observed among the groups. Acute bronchodilator responsiveness in COPD persons was associated with less obstruction and never smoking. Conclusions Over two-thirds of persons with COPD did not demonstrate acute bronchodilator responsiveness. The overall response was small and less than that considered as significant by ATS criteria. The overlap in FEV1 and FVC changes after bronchodilator among the groups makes it difficult to determine a threshold for separating them.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>19818867</pmid><doi>10.1016/j.pupt.2009.09.005</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Bronchi - physiopathology Bronchodilator Chronic obstructive pulmonary disease Epidemiology asthma/COPD Female Forced Expiratory Volume Humans Male Medical Education Middle Aged Multivariate Analysis Prevalence Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary/Respiratory |
| title | Acute bronchodilator responsiveness in subjects with and without airflow obstruction in five Latin American cities: The PLATINO study |
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