X-ray structure analysis of 3,11,17-trioxoandrostane-5α-carbonitrile and of 17α-ethoxycarbonyloxy-3-oxoandrost-4-ene-17-carbonitrile

The crystal and molecular structures of the title compounds were determined by x-ray diffractometric analysis. Torsion angles and puckering parameters are reported for both compounds. In 1 the 5α-cyano group influences the A-ring conformation. The carbonate ester 3 crystallizes in the monoclinic P2...

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Veröffentlicht in:	Steroids 1992-10, Vol.57 (10), p.502-506
Hauptverfasser:	Donati, Donate, Ginanneschi, Mauro, Chelli, Mario, Rapi, Gianfranco, Maria Papini, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry androstane-5-carbonitrile Androstanes - chemistry androstene-17-carbonate Androstenes - chemistry Biological and medical sciences conformation Fundamental and applied biological sciences. Psychology Models, Molecular Molecular Conformation Molecular Structure Other biological molecules ray steroids structure Terpenes, steroids. Hormones X-Ray Diffraction
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Beschreibung
Zusammenfassung:	The crystal and molecular structures of the title compounds were determined by x-ray diffractometric analysis. Torsion angles and puckering parameters are reported for both compounds. In 1 the 5α-cyano group influences the A-ring conformation. The carbonate ester 3 crystallizes in the monoclinic P2 1 space group with two molecules ( I and II) in the asymmetric unit. The D-ring conformation is to some extent different between I and II . ( Steroids 57:502–506, 1992)
ISSN:	0039-128X 1878-5867
DOI:	10.1016/0039-128X(92)90045-B