Erythrocyte Membrane Surface after Calibrated Electroporation: Visualization by Atomic Force Microscopy

Atomic force microscopy was used for examination of the surface of human erythrocyte membrane after calibrated electroporation and application of pharmacological agents. Three-order surface inhomogeneities were revealed with various spectral windows of Fourier transform to elaborate the quantitative...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2009-09, Vol.148 (3), p.455-460
Hauptverfasser:	Chernysh, A. M, Kozlova, E. K, Moroz, V. V, Borshagovskaya, P. Yu, Bliznuk, U. A, Rysaeva, R. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult atomic-force microscopy Biomedical and Life Sciences Biomedicine Cell Biology Electroporation erythrocyte membrane Erythrocyte Membrane - chemistry Erythrocyte Membrane - metabolism Humans Internal Medicine Laboratory Medicine Male Microscopy, Atomic Force - methods Pathology
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Zusammenfassung:	Atomic force microscopy was used for examination of the surface of human erythrocyte membrane after calibrated electroporation and application of pharmacological agents. Three-order surface inhomogeneities were revealed with various spectral windows of Fourier transform to elaborate the quantitative criteria to assess the state of membrane surface. The size of structural alterations induced in the membranes by electroporation was 100-300 nm, which is comparable to the size of membrane matrix.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-010-0735-4