Effect of Ultralow Doses of Antibodies to S-100 Protein in Animals with Impaired Cognitive Function and Disturbed Emotional and Neurological Status under Conditions of Experimental Alzheimer Disease

Course administration of ultralow doses of antibodies to S-100 protein restores cognitive functions and neurological status, improves emotional state, and reduces anxiety in animals with modeled Alzheimer disease based on cholinergic system defi ciency caused by subchronic treatment with scopolamine...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2009-09, Vol.148 (3), p.533-535
Hauptverfasser:	Voronina, T. A, Belopol'skaya, M. V, Kheyfets, I. A, Dugina, Yu. L, Sergeeva, S. A, Epshtein, O. I
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer disease Alzheimer Disease - drug therapy Alzheimer Disease - pathology Animals Antibodies - immunology Antibodies - therapeutic use Anxiety - drug therapy Avoidance Learning - drug effects Biomedical and Life Sciences Biomedicine Cell Biology Cognition - drug effects Cognition Disorders - drug therapy Internal Medicine Laboratory Medicine Male Neuropsychological Tests Pathology Rats S-100 protein S100 Proteins - immunology scopolamine Scopolamine - therapeutic use ultralow doses
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Beschreibung
Zusammenfassung:	Course administration of ultralow doses of antibodies to S-100 protein restores cognitive functions and neurological status, improves emotional state, and reduces anxiety in animals with modeled Alzheimer disease based on cholinergic system defi ciency caused by subchronic treatment with scopolamine.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-010-0757-y