Treatment with Monoclonal Antibodies against Clostridium difficile Toxins

To the Editor: The findings by Lowy and colleagues (Jan. 21 issue) 1 demonstrate the value of fully human monoclonal antibodies in preventing the recurrence of Clostridium difficile infection. The prevalence of C. difficile infection in hospitalized patients is greatest among patients older than 85...

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Veröffentlicht in:The New England journal of medicine 2010-04, Vol.362 (15), p.1444-1446
Hauptverfasser: Parks, Tom, Gkrania-Klotsas, Effrossyni, Nicholl, Claire
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Sprache:eng
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Zusammenfassung:To the Editor: The findings by Lowy and colleagues (Jan. 21 issue) 1 demonstrate the value of fully human monoclonal antibodies in preventing the recurrence of Clostridium difficile infection. The prevalence of C. difficile infection in hospitalized patients is greatest among patients older than 85 years of age, 2 and recurrent C. difficile infection is both more frequent and more problematic in older adults. 3 Although the oldest patient in the trial conducted by Lowy et al. was 101 years old, the mean age was 64 years. We recently reported that the natural history of C. difficile infection in frail, elderly patients is . . .
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMc1002213