Use of a non-specific immunomodulation therapy as a therapeutic vasculogenesis strategy in no-option critical limb ischemia patients
Abstract Background/aims Inflammatory mediators contribute to the impairment of vasculogenesis by reducing endothelial progenitor cells (EPCs) mobilization in atherosclerotic vasculopathy. We tested the hypothesis that administration of an oxygen/ozone mixture (IMT) might counteract this pathophysio...
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Veröffentlicht in: | Atherosclerosis 2010-02, Vol.208 (2), p.473-479 |
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Hauptverfasser: | , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Abstract Background/aims Inflammatory mediators contribute to the impairment of vasculogenesis by reducing endothelial progenitor cells (EPCs) mobilization in atherosclerotic vasculopathy. We tested the hypothesis that administration of an oxygen/ozone mixture (IMT) might counteract this pathophysiological mechanism and enhance limb tissue perfusion in patients with critical limb ischemia (CLI). Methods Randomized patients with rest pain or ischemic ulcers and transcutaneous oxygen tension (TcPO2 ) |
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ISSN: | 0021-9150 1879-1484 |
DOI: | 10.1016/j.atherosclerosis.2009.08.005 |