Intraspecies transmission of L-type-like bovine spongiform encephalopathy detected in Japan

ABSTRACT It has been assumed that the agent causing BSE in cattle is a uniform strain (classical BSE); however, different neuropathological and molecular phenotypes of BSE (atypical BSE) have been recently reported. We demonstrated the successful transmission of L‐type‐like atypical BSE detected in...

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Veröffentlicht in:Microbiology and immunology 2009-12, Vol.53 (12), p.704-707
Hauptverfasser: Fukuda, Shigeo, Iwamaru, Yoshifumi, Imamura, Morikazu, Masujin, Kentarou, Shimizu, Yoshihisa, Matsuura, Yuichi, Shu, Yujing, Kurachi, Megumi, Kasai, Kazuo, Murayama, Yuichi, Onoe, Sadao, Hagiwara, Ken'ichi, Sata, Tetsutaro, Mohri, Shirou, Yokoyama, Takashi, Okada, Hiroyuki
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Sprache:eng
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Zusammenfassung:ABSTRACT It has been assumed that the agent causing BSE in cattle is a uniform strain (classical BSE); however, different neuropathological and molecular phenotypes of BSE (atypical BSE) have been recently reported. We demonstrated the successful transmission of L‐type‐like atypical BSE detected in Japan (BSE/JP24 isolate) to cattle. Based on the incubation period, neuropathological hallmarks, and molecular properties of the abnormal host prion protein, the characteristics of BSE/JP24 prion were apparently distinguishable from the classical BSE prion and closely resemble those of bovine amyloidotic spongiform encephalopathy prion detected in Italy.
ISSN:0385-5600
1348-0421
DOI:10.1111/j.1348-0421.2009.00169.x