Exchange transfusion of least incompatible blood for severe hemolytic disease of the newborn due to anti-Rh17

HDN attributed to the rare Rh variants has become more and more significant caused by anti‐D, but the compatible blood is usually very difficult to obtain when exchange transfusion is required. We treated a 10‐hour neonate of O, D + C + c − E − e + blood group with severe HDN due to anti‐Rh17 with least incompatible blood typed O, D + C − c + E + e −. The neonatal hemolysis was relieved obviously and bilirubin was reduced gradually after exchange transfusion. The infant was discharged in good health 13 days after birth with 135.0 g/L, 28.0 μmol/L and 10.7 μmol/L of Hb, total bilirubin and direct bilirubin, respectively. No sequelae were observed in a three‐year follow‐up. The result suggesting that the least incompatible blood is an alternative choice for exchange transfusion in severe HDN due to anti‐Rh17 in case that Rh17 antigen‐negative blood is unavailable.