Essential tremor is not associated with α-synuclein gene haplotypes

A specific allele of the NACP‐Rep1 polymorphism within the α‐synuclein promoter was found to be associated both with Parkinson's disease and essential tremor. We repeated the association study on a large series of Italian patients with essential tremor using a panel of polymorphisms within the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Movement disorders 2003-07, Vol.18 (7), p.823-826
Hauptverfasser:	Pigullo, Simona, Di Maria, Emilio, Marchese, Roberta, Bellone, Emilia, Gulli, Rossella, Scaglione, Cesa, Battaglia, Stella, Barone, Paolo, Martinelli, Paolo, Abbruzzese, Giovanni, Ajmar, Franco, Mandich, Paola
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alleles alpha-Synuclein association study Biological and medical sciences essential tremor Essential Tremor - diagnosis Essential Tremor - genetics Female Gene Frequency - genetics Genetic Predisposition to Disease - genetics Haplotypes Humans Italy Male Medical sciences Middle Aged NACP Nerve Tissue Proteins - genetics Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Parkinson Disease - diagnosis Parkinson Disease - genetics Polymorphism, Genetic - genetics Promoter Regions, Genetic - genetics Synucleins α-synuclein
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A specific allele of the NACP‐Rep1 polymorphism within the α‐synuclein promoter was found to be associated both with Parkinson's disease and essential tremor. We repeated the association study on a large series of Italian patients with essential tremor using a panel of polymorphisms within the α‐synuclein gene. Our results did not confirm the association reported previously and failed to identify a α‐synuclein specific haplotype as susceptibility factor for essential tremor. © 2003 Movement Disorder Society
ISSN:	0885-3185 1531-8257
DOI:	10.1002/mds.10421