Cortical electrical stimulation alone enhances functional recovery and dendritic structures after focal cerebral ischemia in rats
Abstract Using a fully implanted cortical electrical stimulation (CES) device with low-frequency burst impulse train, we investigated the effects of CES alone on behavioral recovery and surface density of dendritic structure in a rat model of middle cerebral artery occlusion (MCAO). After MCAO in ra...
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description | Abstract Using a fully implanted cortical electrical stimulation (CES) device with low-frequency burst impulse train, we investigated the effects of CES alone on behavioral recovery and surface density of dendritic structure in a rat model of middle cerebral artery occlusion (MCAO). After MCAO in rats, magnetic resonance imaging (MRI) was used to confirm cortex infarction and to identify a location for implantation of stimulating electrode over the peri-infarct cortex. The device was implanted on the 6th day after MCAO with CES then lasting for 16 days. The stimulation program consisted of two sessions lasting half an hour in the morning (0.65 mA, 0.13 μC/phase) and in the afternoon (0.5 mA, 0.1 μC/phase). The stimulator delivered biphasic charge balanced pulses (pulse width = 200 μs) with various frequencies of 50 Hz, 20 Hz and 5 Hz in repeated 10-s blocks. Rats in the CES group ( n = 12) spend a much shorter time to regain preoperative levels of body weight (BW) than those in the no stimulation (NS) group ( n = 9). In behavioral tests, the rats in the CES group showed greater functional recovery compared to the NS group. Moreover, the functional improvement coincided with an increase in surface density of dendritic processes immunoreactive to microtubule-associated protein 2 (MAP2) in peri-infarct cortex. These results suggest the feasibility of the fully implanted CES device and the efficacy of the new stimulation protocol alone to improve functional outcome and cortical neuronal structural plasticity following focal cerebral ischemia in rats. |
doi_str_mv | 10.1016/j.brainres.2009.11.022 |
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After MCAO in rats, magnetic resonance imaging (MRI) was used to confirm cortex infarction and to identify a location for implantation of stimulating electrode over the peri-infarct cortex. The device was implanted on the 6th day after MCAO with CES then lasting for 16 days. The stimulation program consisted of two sessions lasting half an hour in the morning (0.65 mA, 0.13 μC/phase) and in the afternoon (0.5 mA, 0.1 μC/phase). The stimulator delivered biphasic charge balanced pulses (pulse width = 200 μs) with various frequencies of 50 Hz, 20 Hz and 5 Hz in repeated 10-s blocks. Rats in the CES group ( n = 12) spend a much shorter time to regain preoperative levels of body weight (BW) than those in the no stimulation (NS) group ( n = 9). In behavioral tests, the rats in the CES group showed greater functional recovery compared to the NS group. Moreover, the functional improvement coincided with an increase in surface density of dendritic processes immunoreactive to microtubule-associated protein 2 (MAP2) in peri-infarct cortex. These results suggest the feasibility of the fully implanted CES device and the efficacy of the new stimulation protocol alone to improve functional outcome and cortical neuronal structural plasticity following focal cerebral ischemia in rats.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2009.11.022</identifier><identifier>PMID: 19941838</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Body Weight - physiology ; Brain - pathology ; Brain - physiopathology ; Brain Ischemia - pathology ; Brain Ischemia - physiopathology ; Brain Ischemia - therapy ; Cortical electrical stimulation ; Dendrites - physiology ; Disease Models, Animal ; Electric Stimulation Therapy - methods ; Electrodes, Implanted ; Focal cerebral ischemia ; Functional recovery ; Immunohistochemistry ; Infarction, Middle Cerebral Artery - pathology ; Infarction, Middle Cerebral Artery - physiopathology ; Infarction, Middle Cerebral Artery - therapy ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Microelectrodes ; Microtubule-associated protein 2 (MAP2) ; Microtubule-Associated Proteins - metabolism ; Neurology ; Neuropsychological Tests ; Plasticity ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Recovery of Function - physiology ; Time Factors ; Treatment Outcome ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Brain research, 2010-01, Vol.1311, p.148-157</ispartof><rights>Elsevier B.V.</rights><rights>2009 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2009 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-1e54af3c4121dbc80f23266e663f71daf346c012385ed467a79f8e82f51912513</citedby><cites>FETCH-LOGICAL-c452t-1e54af3c4121dbc80f23266e663f71daf346c012385ed467a79f8e82f51912513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006899309024482$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22895508$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19941838$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Qin</creatorcontrib><creatorcontrib>Zhang, Qian</creatorcontrib><creatorcontrib>Zhao, Xueqing</creatorcontrib><creatorcontrib>Duan, Yanwen Y</creatorcontrib><creatorcontrib>Lu, Yi</creatorcontrib><creatorcontrib>Li, Chengyan</creatorcontrib><creatorcontrib>Li, Tao</creatorcontrib><title>Cortical electrical stimulation alone enhances functional recovery and dendritic structures after focal cerebral ischemia in rats</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Abstract Using a fully implanted cortical electrical stimulation (CES) device with low-frequency burst impulse train, we investigated the effects of CES alone on behavioral recovery and surface density of dendritic structure in a rat model of middle cerebral artery occlusion (MCAO). After MCAO in rats, magnetic resonance imaging (MRI) was used to confirm cortex infarction and to identify a location for implantation of stimulating electrode over the peri-infarct cortex. The device was implanted on the 6th day after MCAO with CES then lasting for 16 days. The stimulation program consisted of two sessions lasting half an hour in the morning (0.65 mA, 0.13 μC/phase) and in the afternoon (0.5 mA, 0.1 μC/phase). The stimulator delivered biphasic charge balanced pulses (pulse width = 200 μs) with various frequencies of 50 Hz, 20 Hz and 5 Hz in repeated 10-s blocks. Rats in the CES group ( n = 12) spend a much shorter time to regain preoperative levels of body weight (BW) than those in the no stimulation (NS) group ( n = 9). In behavioral tests, the rats in the CES group showed greater functional recovery compared to the NS group. Moreover, the functional improvement coincided with an increase in surface density of dendritic processes immunoreactive to microtubule-associated protein 2 (MAP2) in peri-infarct cortex. These results suggest the feasibility of the fully implanted CES device and the efficacy of the new stimulation protocol alone to improve functional outcome and cortical neuronal structural plasticity following focal cerebral ischemia in rats.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight - physiology</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Brain Ischemia - pathology</subject><subject>Brain Ischemia - physiopathology</subject><subject>Brain Ischemia - therapy</subject><subject>Cortical electrical stimulation</subject><subject>Dendrites - physiology</subject><subject>Disease Models, Animal</subject><subject>Electric Stimulation Therapy - methods</subject><subject>Electrodes, Implanted</subject><subject>Focal cerebral ischemia</subject><subject>Functional recovery</subject><subject>Immunohistochemistry</subject><subject>Infarction, Middle Cerebral Artery - pathology</subject><subject>Infarction, Middle Cerebral Artery - physiopathology</subject><subject>Infarction, Middle Cerebral Artery - therapy</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microelectrodes</subject><subject>Microtubule-associated protein 2 (MAP2)</subject><subject>Microtubule-Associated Proteins - metabolism</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Plasticity</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Recovery of Function - physiology</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkuLFDEUhYMoTs_oXxiyEVdV5lWpZCNKo6Mw4EJdh3TqhklbnYxJaqCX_nNTdqvgxlVe554cvnsRuqakp4TKV_t-l22IGUrPCNE9pT1h7BHaUDWyTjJBHqMNIUR2Smt-gS5L2bcj55o8RRdUa0EVVxv0Y5tyDc7OGGZwNf_alhoOy2xrSBHbOUXAEO9sdFCwX6Jb75sqg0sPkI_YxglPEKccmlMrzourS0uGra-QsU-rp4MMLfKMQ3F3cAgWh4izreUZeuLtXOD5eb1CX9-_-7L90N1-uvm4fXvbOTGw2lEYhPXcCcrotHOKeMaZlCAl9yOd2pOQjlDG1QCTkKMdtVegmB-opmyg_Aq9PPne5_R9gVLNoUWBebYR0lLMyLmSbBSiKeVJ6XIqJYM39zkcbD4aSsxK3-zNb_pmpW8oNY1-K7w-f7HsDjD9LTvjboIXZ4EtDYrPDWoof3SMKT0MZNW9OemgAXkIkE1xAVoDptCoVzOl8P8sr_-xcHOIa3u_wRHKPi25NbEYagozxHxeZ2UdFaIJE0Ix_hNINb3N</recordid><startdate>20100122</startdate><enddate>20100122</enddate><creator>Zhou, Qin</creator><creator>Zhang, Qian</creator><creator>Zhao, Xueqing</creator><creator>Duan, Yanwen Y</creator><creator>Lu, Yi</creator><creator>Li, Chengyan</creator><creator>Li, Tao</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100122</creationdate><title>Cortical electrical stimulation alone enhances functional recovery and dendritic structures after focal cerebral ischemia in rats</title><author>Zhou, Qin ; Zhang, Qian ; Zhao, Xueqing ; Duan, Yanwen Y ; Lu, Yi ; Li, Chengyan ; Li, Tao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-1e54af3c4121dbc80f23266e663f71daf346c012385ed467a79f8e82f51912513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight - physiology</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>Brain Ischemia - pathology</topic><topic>Brain Ischemia - physiopathology</topic><topic>Brain Ischemia - therapy</topic><topic>Cortical electrical stimulation</topic><topic>Dendrites - physiology</topic><topic>Disease Models, Animal</topic><topic>Electric Stimulation Therapy - methods</topic><topic>Electrodes, Implanted</topic><topic>Focal cerebral ischemia</topic><topic>Functional recovery</topic><topic>Immunohistochemistry</topic><topic>Infarction, Middle Cerebral Artery - pathology</topic><topic>Infarction, Middle Cerebral Artery - physiopathology</topic><topic>Infarction, Middle Cerebral Artery - therapy</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microelectrodes</topic><topic>Microtubule-associated protein 2 (MAP2)</topic><topic>Microtubule-Associated Proteins - metabolism</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Plasticity</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Recovery of Function - physiology</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Qin</creatorcontrib><creatorcontrib>Zhang, Qian</creatorcontrib><creatorcontrib>Zhao, Xueqing</creatorcontrib><creatorcontrib>Duan, Yanwen Y</creatorcontrib><creatorcontrib>Lu, Yi</creatorcontrib><creatorcontrib>Li, Chengyan</creatorcontrib><creatorcontrib>Li, Tao</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Qin</au><au>Zhang, Qian</au><au>Zhao, Xueqing</au><au>Duan, Yanwen Y</au><au>Lu, Yi</au><au>Li, Chengyan</au><au>Li, Tao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cortical electrical stimulation alone enhances functional recovery and dendritic structures after focal cerebral ischemia in rats</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2010-01-22</date><risdate>2010</risdate><volume>1311</volume><spage>148</spage><epage>157</epage><pages>148-157</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Abstract Using a fully implanted cortical electrical stimulation (CES) device with low-frequency burst impulse train, we investigated the effects of CES alone on behavioral recovery and surface density of dendritic structure in a rat model of middle cerebral artery occlusion (MCAO). After MCAO in rats, magnetic resonance imaging (MRI) was used to confirm cortex infarction and to identify a location for implantation of stimulating electrode over the peri-infarct cortex. The device was implanted on the 6th day after MCAO with CES then lasting for 16 days. The stimulation program consisted of two sessions lasting half an hour in the morning (0.65 mA, 0.13 μC/phase) and in the afternoon (0.5 mA, 0.1 μC/phase). The stimulator delivered biphasic charge balanced pulses (pulse width = 200 μs) with various frequencies of 50 Hz, 20 Hz and 5 Hz in repeated 10-s blocks. Rats in the CES group ( n = 12) spend a much shorter time to regain preoperative levels of body weight (BW) than those in the no stimulation (NS) group ( n = 9). In behavioral tests, the rats in the CES group showed greater functional recovery compared to the NS group. Moreover, the functional improvement coincided with an increase in surface density of dendritic processes immunoreactive to microtubule-associated protein 2 (MAP2) in peri-infarct cortex. These results suggest the feasibility of the fully implanted CES device and the efficacy of the new stimulation protocol alone to improve functional outcome and cortical neuronal structural plasticity following focal cerebral ischemia in rats.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>19941838</pmid><doi>10.1016/j.brainres.2009.11.022</doi><tpages>10</tpages></addata></record> |
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subjects | Animals Biological and medical sciences Body Weight - physiology Brain - pathology Brain - physiopathology Brain Ischemia - pathology Brain Ischemia - physiopathology Brain Ischemia - therapy Cortical electrical stimulation Dendrites - physiology Disease Models, Animal Electric Stimulation Therapy - methods Electrodes, Implanted Focal cerebral ischemia Functional recovery Immunohistochemistry Infarction, Middle Cerebral Artery - pathology Infarction, Middle Cerebral Artery - physiopathology Infarction, Middle Cerebral Artery - therapy Magnetic Resonance Imaging Male Medical sciences Microelectrodes Microtubule-associated protein 2 (MAP2) Microtubule-Associated Proteins - metabolism Neurology Neuropsychological Tests Plasticity Random Allocation Rats Rats, Sprague-Dawley Recovery of Function - physiology Time Factors Treatment Outcome Vascular diseases and vascular malformations of the nervous system |
title | Cortical electrical stimulation alone enhances functional recovery and dendritic structures after focal cerebral ischemia in rats |
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