Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid
Summary Background/aims Lactobionic acid (LA) is a newer cosmeceutical active belonging to the class of alpha‐hydroxyacids (AHAs), showing advantages over them. The aim of part I of this study was to compare efficacy and irritation potential of LA vs. glycolic acid (GA) from two types of vehicles –...
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| Veröffentlicht in: | Journal of cosmetic dermatology 2010-03, Vol.9 (1), p.3-10 |
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| creator | Tasic-Kostov, Marija Savic, Snezana Lukic, Milica Tamburic, Slobodanka Pavlovic, Milos Vuleta, Gordana |
| description | Summary
Background/aims Lactobionic acid (LA) is a newer cosmeceutical active belonging to the class of alpha‐hydroxyacids (AHAs), showing advantages over them. The aim of part I of this study was to compare efficacy and irritation potential of LA vs. glycolic acid (GA) from two types of vehicles – gel and emulsion. In part II, effects of LA‐containing emulsions based on a new, natural emulsifier of alkylpolyglucoside (APG) type were evaluated.
Methods Skin bioengineering was used on 77 healthy volunteers to assess: color as erythema and melanin (MI) index, transepidermal water loss, electrical capacitance and pH of the skin. In part I of the study, the parameters were measured after occlusion and periodically during 2 weeks of test samples application; in part II parameters were measured periodically during 4 weeks.
Results/conclusion LA‐containing samples has produced better skin performance when compared with corresponding GA‐containing ones, particularly the lack of both skin irritation and skin barrier impairment. When used in vehicles based on a new APG‐emulsifier, LA and GA have shown better efficacy, emphasizing the importance of vehicle on the effects of topical actives. LA (6%) in the emulsion based on APGs could be proposed as an alternative to low‐molecular AHAs in cosmeceuticals. |
| doi_str_mv | 10.1111/j.1473-2165.2010.00474.x |
| format | Article |
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Background/aims Lactobionic acid (LA) is a newer cosmeceutical active belonging to the class of alpha‐hydroxyacids (AHAs), showing advantages over them. The aim of part I of this study was to compare efficacy and irritation potential of LA vs. glycolic acid (GA) from two types of vehicles – gel and emulsion. In part II, effects of LA‐containing emulsions based on a new, natural emulsifier of alkylpolyglucoside (APG) type were evaluated.
Methods Skin bioengineering was used on 77 healthy volunteers to assess: color as erythema and melanin (MI) index, transepidermal water loss, electrical capacitance and pH of the skin. In part I of the study, the parameters were measured after occlusion and periodically during 2 weeks of test samples application; in part II parameters were measured periodically during 4 weeks.
Results/conclusion LA‐containing samples has produced better skin performance when compared with corresponding GA‐containing ones, particularly the lack of both skin irritation and skin barrier impairment. When used in vehicles based on a new APG‐emulsifier, LA and GA have shown better efficacy, emphasizing the importance of vehicle on the effects of topical actives. LA (6%) in the emulsion based on APGs could be proposed as an alternative to low‐molecular AHAs in cosmeceuticals.</description><identifier>ISSN: 1473-2130</identifier><identifier>EISSN: 1473-2165</identifier><identifier>DOI: 10.1111/j.1473-2165.2010.00474.x</identifier><identifier>PMID: 20367666</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Administration, Cutaneous ; Adult ; bioengineering of the skin ; cosmeceuticals ; Disaccharides - administration & dosage ; Disaccharides - adverse effects ; Disaccharides - pharmacology ; emulsifiers ; Emulsions - pharmacology ; Fatty Alcohols - pharmacology ; Female ; Gels - pharmacology ; Glucosides - pharmacology ; Glycolates - administration & dosage ; Glycolates - adverse effects ; Glycolates - pharmacology ; glycolic acid ; Humans ; Keratolytic Agents - administration & dosage ; Keratolytic Agents - adverse effects ; Keratolytic Agents - pharmacology ; lactobionic acid ; Male ; Pharmaceutical Vehicles - pharmacology ; Reference Values ; safety ; Skin Irritancy Tests ; Sunscreening Agents - administration & dosage ; Sunscreening Agents - adverse effects ; Sunscreening Agents - pharmacology</subject><ispartof>Journal of cosmetic dermatology, 2010-03, Vol.9 (1), p.3-10</ispartof><rights>2010 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4064-eb8612becec3d51240555d01efb90f27d442b3a819869fb4ef28e3f82f660ce83</citedby><cites>FETCH-LOGICAL-c4064-eb8612becec3d51240555d01efb90f27d442b3a819869fb4ef28e3f82f660ce83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1473-2165.2010.00474.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1473-2165.2010.00474.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20367666$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tasic-Kostov, Marija</creatorcontrib><creatorcontrib>Savic, Snezana</creatorcontrib><creatorcontrib>Lukic, Milica</creatorcontrib><creatorcontrib>Tamburic, Slobodanka</creatorcontrib><creatorcontrib>Pavlovic, Milos</creatorcontrib><creatorcontrib>Vuleta, Gordana</creatorcontrib><title>Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid</title><title>Journal of cosmetic dermatology</title><addtitle>J Cosmet Dermatol</addtitle><description>Summary
Background/aims Lactobionic acid (LA) is a newer cosmeceutical active belonging to the class of alpha‐hydroxyacids (AHAs), showing advantages over them. The aim of part I of this study was to compare efficacy and irritation potential of LA vs. glycolic acid (GA) from two types of vehicles – gel and emulsion. In part II, effects of LA‐containing emulsions based on a new, natural emulsifier of alkylpolyglucoside (APG) type were evaluated.
Methods Skin bioengineering was used on 77 healthy volunteers to assess: color as erythema and melanin (MI) index, transepidermal water loss, electrical capacitance and pH of the skin. In part I of the study, the parameters were measured after occlusion and periodically during 2 weeks of test samples application; in part II parameters were measured periodically during 4 weeks.
Results/conclusion LA‐containing samples has produced better skin performance when compared with corresponding GA‐containing ones, particularly the lack of both skin irritation and skin barrier impairment. When used in vehicles based on a new APG‐emulsifier, LA and GA have shown better efficacy, emphasizing the importance of vehicle on the effects of topical actives. LA (6%) in the emulsion based on APGs could be proposed as an alternative to low‐molecular AHAs in cosmeceuticals.</description><subject>Administration, Cutaneous</subject><subject>Adult</subject><subject>bioengineering of the skin</subject><subject>cosmeceuticals</subject><subject>Disaccharides - administration & dosage</subject><subject>Disaccharides - adverse effects</subject><subject>Disaccharides - pharmacology</subject><subject>emulsifiers</subject><subject>Emulsions - pharmacology</subject><subject>Fatty Alcohols - pharmacology</subject><subject>Female</subject><subject>Gels - pharmacology</subject><subject>Glucosides - pharmacology</subject><subject>Glycolates - administration & dosage</subject><subject>Glycolates - adverse effects</subject><subject>Glycolates - pharmacology</subject><subject>glycolic acid</subject><subject>Humans</subject><subject>Keratolytic Agents - administration & dosage</subject><subject>Keratolytic Agents - adverse effects</subject><subject>Keratolytic Agents - pharmacology</subject><subject>lactobionic acid</subject><subject>Male</subject><subject>Pharmaceutical Vehicles - pharmacology</subject><subject>Reference Values</subject><subject>safety</subject><subject>Skin Irritancy Tests</subject><subject>Sunscreening Agents - administration & dosage</subject><subject>Sunscreening Agents - adverse effects</subject><subject>Sunscreening Agents - pharmacology</subject><issn>1473-2130</issn><issn>1473-2165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUcuO0zAUtRAjZhj4BeQdqxS_4qRILFCBgVE1IyReO8txros7bhxyE2j28-EktHQ93tyHzzlXOocQytmCT-_VdsFVITPBdb4QbNoypgq12D8iF6ePx6desnPyFHHLGC-WPH9CzgWTutBaX5D7tXV9qkJqgqPWhZqGhlra2H7obKQ23o2xTXHcxMElDDVklUWo6W_4GVyE19QiAmJoNhSth36ktqkpeB-cddOALbgeZ1GXdq3tAqaG9olu4uhSPN58Rs68jQjPj_WSfP3w_svqY7a-vfq0ervOnGJaZVCVmosKHDhZ51wolud5zTj4asm8KGqlRCVtyZelXvpKgRclSF8KrzVzUMpL8vKg23bp1wDYm11ABzHaBtKAppCyzLXifEKWB6TrEmIH3rRd2NluNJyZOQKzNbO7ZnbazBGYfxGY_UR9cTwyVDuoT8T_nk-ANwfAnxBhfLCwub5dvZu6iZ8d-AF72J_4trszupBFbr7fXJlv10L-UEKZz_IvmEamWg</recordid><startdate>201003</startdate><enddate>201003</enddate><creator>Tasic-Kostov, Marija</creator><creator>Savic, Snezana</creator><creator>Lukic, Milica</creator><creator>Tamburic, Slobodanka</creator><creator>Pavlovic, Milos</creator><creator>Vuleta, Gordana</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201003</creationdate><title>Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid</title><author>Tasic-Kostov, Marija ; Savic, Snezana ; Lukic, Milica ; Tamburic, Slobodanka ; Pavlovic, Milos ; Vuleta, Gordana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4064-eb8612becec3d51240555d01efb90f27d442b3a819869fb4ef28e3f82f660ce83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Administration, Cutaneous</topic><topic>Adult</topic><topic>bioengineering of the skin</topic><topic>cosmeceuticals</topic><topic>Disaccharides - administration & dosage</topic><topic>Disaccharides - adverse effects</topic><topic>Disaccharides - pharmacology</topic><topic>emulsifiers</topic><topic>Emulsions - pharmacology</topic><topic>Fatty Alcohols - pharmacology</topic><topic>Female</topic><topic>Gels - pharmacology</topic><topic>Glucosides - pharmacology</topic><topic>Glycolates - administration & dosage</topic><topic>Glycolates - adverse effects</topic><topic>Glycolates - pharmacology</topic><topic>glycolic acid</topic><topic>Humans</topic><topic>Keratolytic Agents - administration & dosage</topic><topic>Keratolytic Agents - adverse effects</topic><topic>Keratolytic Agents - pharmacology</topic><topic>lactobionic acid</topic><topic>Male</topic><topic>Pharmaceutical Vehicles - pharmacology</topic><topic>Reference Values</topic><topic>safety</topic><topic>Skin Irritancy Tests</topic><topic>Sunscreening Agents - administration & dosage</topic><topic>Sunscreening Agents - adverse effects</topic><topic>Sunscreening Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tasic-Kostov, Marija</creatorcontrib><creatorcontrib>Savic, Snezana</creatorcontrib><creatorcontrib>Lukic, Milica</creatorcontrib><creatorcontrib>Tamburic, Slobodanka</creatorcontrib><creatorcontrib>Pavlovic, Milos</creatorcontrib><creatorcontrib>Vuleta, Gordana</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cosmetic dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tasic-Kostov, Marija</au><au>Savic, Snezana</au><au>Lukic, Milica</au><au>Tamburic, Slobodanka</au><au>Pavlovic, Milos</au><au>Vuleta, Gordana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid</atitle><jtitle>Journal of cosmetic dermatology</jtitle><addtitle>J Cosmet Dermatol</addtitle><date>2010-03</date><risdate>2010</risdate><volume>9</volume><issue>1</issue><spage>3</spage><epage>10</epage><pages>3-10</pages><issn>1473-2130</issn><eissn>1473-2165</eissn><abstract>Summary
Background/aims Lactobionic acid (LA) is a newer cosmeceutical active belonging to the class of alpha‐hydroxyacids (AHAs), showing advantages over them. The aim of part I of this study was to compare efficacy and irritation potential of LA vs. glycolic acid (GA) from two types of vehicles – gel and emulsion. In part II, effects of LA‐containing emulsions based on a new, natural emulsifier of alkylpolyglucoside (APG) type were evaluated.
Methods Skin bioengineering was used on 77 healthy volunteers to assess: color as erythema and melanin (MI) index, transepidermal water loss, electrical capacitance and pH of the skin. In part I of the study, the parameters were measured after occlusion and periodically during 2 weeks of test samples application; in part II parameters were measured periodically during 4 weeks.
Results/conclusion LA‐containing samples has produced better skin performance when compared with corresponding GA‐containing ones, particularly the lack of both skin irritation and skin barrier impairment. When used in vehicles based on a new APG‐emulsifier, LA and GA have shown better efficacy, emphasizing the importance of vehicle on the effects of topical actives. LA (6%) in the emulsion based on APGs could be proposed as an alternative to low‐molecular AHAs in cosmeceuticals.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20367666</pmid><doi>10.1111/j.1473-2165.2010.00474.x</doi><tpages>8</tpages></addata></record> |
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| subjects | Administration, Cutaneous Adult bioengineering of the skin cosmeceuticals Disaccharides - administration & dosage Disaccharides - adverse effects Disaccharides - pharmacology emulsifiers Emulsions - pharmacology Fatty Alcohols - pharmacology Female Gels - pharmacology Glucosides - pharmacology Glycolates - administration & dosage Glycolates - adverse effects Glycolates - pharmacology glycolic acid Humans Keratolytic Agents - administration & dosage Keratolytic Agents - adverse effects Keratolytic Agents - pharmacology lactobionic acid Male Pharmaceutical Vehicles - pharmacology Reference Values safety Skin Irritancy Tests Sunscreening Agents - administration & dosage Sunscreening Agents - adverse effects Sunscreening Agents - pharmacology |
| title | Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid |
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