Highly Enantioselective Intramolecular Copper Catalyzed C−H Insertion Reactions of α-Diazosulfones

Highly Enantioselective Intramolecular Copper Catalyzed C−H Insertion Reactions of α-Diazosulfones

Excellent enantiocontrol (up to 98% ee) is achieved in copper catalyzed C−H insertions of α-diazosulfones to form thiopyrans, with up to 60% ee in C−H insertions leading to sulfolanes.

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Veröffentlicht in:Journal of the American Chemical Society 2010-02, Vol.132 (4), p.1184-1185
Hauptverfasser: Flynn, Christopher J, Elcoate, Curtis J, Lawrence, Simon E, Maguire, Anita R
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Copper - chemistry
Diazonium Compounds - chemistry
Stereoisomerism
Sulfones - chemistry
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Zusammenfassung:Excellent enantiocontrol (up to 98% ee) is achieved in copper catalyzed C−H insertions of α-diazosulfones to form thiopyrans, with up to 60% ee in C−H insertions leading to sulfolanes.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja909713a