Tumor necrosis factor alpha induced by Trypanosoma cruzi infection mediates inflammation and cell death in the liver of infected mice

Trypanosoma cruzi ( T. cruzi) infected C57BL/6 mice developed a progressive fatal disease due to an imbalance in the profile of circulating related compounds accompanying infection like tumor necrosis factor alpha (TNFα). TNFα has been proposed as an important effector molecule in apoptosis. In this...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2010, Vol.49 (1), p.64-72
Hauptverfasser:	Ronco, Maria T., Francés, Daniel E., Ingaramo, Paola I., Quiroga, Ariel D., Alvarez, Maria L., Pisani, Gerardo B., Revelli, Silvia S., Carnovale, Cristina E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis bcl-2-Associated X Protein - immunology bcl-X Protein - immunology BH3 Interacting Domain Death Agonist Protein - immunology Cell Death - immunology Chagas Disease - immunology Cytochromes c - metabolism Humans In Situ Nick-End Labeling Inflammation Inflammation - immunology Inflammation - microbiology Liver Liver - cytology Liver - immunology Liver - parasitology Mice Mice, Inbred C57BL Proto-Oncogene Proteins c-bcl-2 - metabolism Receptors, Tumor Necrosis Factor, Type I - immunology TNFα Trypanosoma cruzi Trypanosoma cruzi - immunology Trypanosoma cruzi - pathogenicity Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology
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