Human Parvovirus B19–Associated Myocarditis

To the Editor: Viral and postviral myocarditis are the major causes of acute and chronic dilated cardiomyopathy. 1 To gain insight into the pathogenesis of parvovirus B19–associated myocarditis as an endothelial-cell–mediated disease (Figure 1A), we measured viral loads in endomyocardial biopsy spec...

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Veröffentlicht in:The New England journal of medicine 2010-04, Vol.362 (13), p.1248-1249
Hauptverfasser: Bock, Claus-Thomas, Klingel, Karin, Kandolf, Reinhard
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Sprache:eng
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Zusammenfassung:To the Editor: Viral and postviral myocarditis are the major causes of acute and chronic dilated cardiomyopathy. 1 To gain insight into the pathogenesis of parvovirus B19–associated myocarditis as an endothelial-cell–mediated disease (Figure 1A), we measured viral loads in endomyocardial biopsy specimens obtained from 498 patients (341 men and 157 women; mean [±SD] age, 46.93±15.85 years) with myocarditis 2 or chronic dilated cardiomyopathy who were positive for parvovirus B19 on immunohistologic analysis. A total of 91 noninflamed normal hearts obtained from autopsies served as controls. We found that parvovirus B19 genomes were significantly more likely to be detected in the endomyocardial biopsy . . .
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMc0911362