Soluble endothelial protein C receptor levels in healthy population
Increased levels of sEPCR lead to dysfunction of EPCR-mediated coagulation. The aim of this present study was to determine plasma sEPCR levels in a group of Turkish healthy population including both adults and children. The study population consisted of 230 healthy individuals (108 children and 122...
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| Veröffentlicht in: | Journal of thrombosis and thrombolysis 2010, Vol.29 (1), p.46-51 |
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| container_title | Journal of thrombosis and thrombolysis |
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| creator | Orhon, Filiz Simsek Ergun, Huseyin Egin, Yonca Ulukol, Betul Baskan, Sevgi Akar, Nejat |
| description | Increased levels of sEPCR lead to dysfunction of EPCR-mediated coagulation. The aim of this present study was to determine plasma sEPCR levels in a group of Turkish healthy population including both adults and children. The study population consisted of 230 healthy individuals (108 children and 122 adults) having no acute or chronic disease. Plasma sEPCR levels were measured with ELISA. Analysis revealed a bimodal distribution in both groups. There was a negative relationship between sEPCR levels and the age of individuals (
r
= −0.385,
P
= 0.0001). The sEPCR levels of children were found significantly higher than that of adults (
P
|
| doi_str_mv | 10.1007/s11239-009-0329-z |
| format | Article |
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r
= −0.385,
P
= 0.0001). The sEPCR levels of children were found significantly higher than that of adults (
P
< 0.001). This study is the first study to determine the relationship of sEPCR levels and terms of age. Higher levels of sEPCR may suggest a regulation mechanism for the protein C anticoagulation system over the first years of life. Further studies should be conducted to evaluate the physiological importance and molecular mechanism of increased sEPCR levels in children.</description><identifier>ISSN: 0929-5305</identifier><identifier>EISSN: 1573-742X</identifier><identifier>DOI: 10.1007/s11239-009-0329-z</identifier><identifier>PMID: 19296056</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aging - blood ; Antigens, CD - blood ; Cardiology ; Child ; Child, Preschool ; Endothelial Protein C Receptor ; Female ; Hematology ; Humans ; Infant ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Receptors, Cell Surface - blood ; Reference Values ; Sex Factors ; Turkey ; Young Adult</subject><ispartof>Journal of thrombosis and thrombolysis, 2010, Vol.29 (1), p.46-51</ispartof><rights>Springer Science+Business Media, LLC 2009</rights><rights>Springer Science+Business Media, LLC 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-1044bb6033f5673c7753e1846020e1d933c4549e7db724ebb2bd3a117f3dd253</citedby><cites>FETCH-LOGICAL-c370t-1044bb6033f5673c7753e1846020e1d933c4549e7db724ebb2bd3a117f3dd253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11239-009-0329-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11239-009-0329-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19296056$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Orhon, Filiz Simsek</creatorcontrib><creatorcontrib>Ergun, Huseyin</creatorcontrib><creatorcontrib>Egin, Yonca</creatorcontrib><creatorcontrib>Ulukol, Betul</creatorcontrib><creatorcontrib>Baskan, Sevgi</creatorcontrib><creatorcontrib>Akar, Nejat</creatorcontrib><title>Soluble endothelial protein C receptor levels in healthy population</title><title>Journal of thrombosis and thrombolysis</title><addtitle>J Thromb Thrombolysis</addtitle><addtitle>J Thromb Thrombolysis</addtitle><description>Increased levels of sEPCR lead to dysfunction of EPCR-mediated coagulation. The aim of this present study was to determine plasma sEPCR levels in a group of Turkish healthy population including both adults and children. The study population consisted of 230 healthy individuals (108 children and 122 adults) having no acute or chronic disease. Plasma sEPCR levels were measured with ELISA. Analysis revealed a bimodal distribution in both groups. There was a negative relationship between sEPCR levels and the age of individuals (
r
= −0.385,
P
= 0.0001). The sEPCR levels of children were found significantly higher than that of adults (
P
< 0.001). This study is the first study to determine the relationship of sEPCR levels and terms of age. Higher levels of sEPCR may suggest a regulation mechanism for the protein C anticoagulation system over the first years of life. Further studies should be conducted to evaluate the physiological importance and molecular mechanism of increased sEPCR levels in children.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - blood</subject><subject>Antigens, CD - blood</subject><subject>Cardiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Endothelial Protein C Receptor</subject><subject>Female</subject><subject>Hematology</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Receptors, Cell Surface - blood</subject><subject>Reference Values</subject><subject>Sex Factors</subject><subject>Turkey</subject><subject>Young Adult</subject><issn>0929-5305</issn><issn>1573-742X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1Lw0AQhhdRbK3-AC8SvHiKzn5lm6MEv6DgwR68LfmY2JRtNu4mQvvr3ZJCQfCwLMw8887wEHJN4Z4CqAdPKeNpDBAeZ2m8OyFTKhWPlWCfp2QKaShKDnJCLrxfQwBTYOdkQkMjAZlMSfZhzVAYjLCtbL9C0-Qm6pztsWmjLHJYYtdbFxn8QeOjUFxhbvrVNupsN5i8b2x7Sc7q3Hi8Ovwzsnx-Wmav8eL95S17XMQlV9DHFIQoigQ4r2WieKmU5EjnIgEGSKuU81JIkaKqCsUEFgUrKp5TqmpeVUzyGbkbY8N53wP6Xm8aX6IxeYt28FpxPhdCCRXI2z_k2g6uDbdpxmCPAQ0QHaHSWe8d1rpzzSZ3W01B7_XqUa8O1vRer96FmZtD8FBssDpOHHwGgI2AD632C91x8_-pv413hLQ</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Orhon, Filiz Simsek</creator><creator>Ergun, Huseyin</creator><creator>Egin, Yonca</creator><creator>Ulukol, Betul</creator><creator>Baskan, Sevgi</creator><creator>Akar, Nejat</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>2010</creationdate><title>Soluble endothelial protein C receptor levels in healthy population</title><author>Orhon, Filiz Simsek ; Ergun, Huseyin ; Egin, Yonca ; Ulukol, Betul ; Baskan, Sevgi ; Akar, Nejat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-1044bb6033f5673c7753e1846020e1d933c4549e7db724ebb2bd3a117f3dd253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - blood</topic><topic>Antigens, CD - blood</topic><topic>Cardiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Endothelial Protein C Receptor</topic><topic>Female</topic><topic>Hematology</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Receptors, Cell Surface - blood</topic><topic>Reference Values</topic><topic>Sex Factors</topic><topic>Turkey</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Orhon, Filiz Simsek</creatorcontrib><creatorcontrib>Ergun, Huseyin</creatorcontrib><creatorcontrib>Egin, Yonca</creatorcontrib><creatorcontrib>Ulukol, Betul</creatorcontrib><creatorcontrib>Baskan, Sevgi</creatorcontrib><creatorcontrib>Akar, Nejat</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of thrombosis and thrombolysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Orhon, Filiz Simsek</au><au>Ergun, Huseyin</au><au>Egin, Yonca</au><au>Ulukol, Betul</au><au>Baskan, Sevgi</au><au>Akar, Nejat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Soluble endothelial protein C receptor levels in healthy population</atitle><jtitle>Journal of thrombosis and thrombolysis</jtitle><stitle>J Thromb Thrombolysis</stitle><addtitle>J Thromb Thrombolysis</addtitle><date>2010</date><risdate>2010</risdate><volume>29</volume><issue>1</issue><spage>46</spage><epage>51</epage><pages>46-51</pages><issn>0929-5305</issn><eissn>1573-742X</eissn><abstract>Increased levels of sEPCR lead to dysfunction of EPCR-mediated coagulation. The aim of this present study was to determine plasma sEPCR levels in a group of Turkish healthy population including both adults and children. The study population consisted of 230 healthy individuals (108 children and 122 adults) having no acute or chronic disease. Plasma sEPCR levels were measured with ELISA. Analysis revealed a bimodal distribution in both groups. There was a negative relationship between sEPCR levels and the age of individuals (
r
= −0.385,
P
= 0.0001). The sEPCR levels of children were found significantly higher than that of adults (
P
< 0.001). This study is the first study to determine the relationship of sEPCR levels and terms of age. Higher levels of sEPCR may suggest a regulation mechanism for the protein C anticoagulation system over the first years of life. Further studies should be conducted to evaluate the physiological importance and molecular mechanism of increased sEPCR levels in children.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>19296056</pmid><doi>10.1007/s11239-009-0329-z</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Aging - blood Antigens, CD - blood Cardiology Child Child, Preschool Endothelial Protein C Receptor Female Hematology Humans Infant Male Medicine Medicine & Public Health Middle Aged Receptors, Cell Surface - blood Reference Values Sex Factors Turkey Young Adult |
| title | Soluble endothelial protein C receptor levels in healthy population |
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