Soluble endothelial protein C receptor levels in healthy population

Increased levels of sEPCR lead to dysfunction of EPCR-mediated coagulation. The aim of this present study was to determine plasma sEPCR levels in a group of Turkish healthy population including both adults and children. The study population consisted of 230 healthy individuals (108 children and 122...

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Veröffentlicht in:	Journal of thrombosis and thrombolysis 2010, Vol.29 (1), p.46-51
Hauptverfasser:	Orhon, Filiz Simsek, Ergun, Huseyin, Egin, Yonca, Ulukol, Betul, Baskan, Sevgi, Akar, Nejat
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Aging - blood Antigens, CD - blood Cardiology Child Child, Preschool Endothelial Protein C Receptor Female Hematology Humans Infant Male Medicine Medicine & Public Health Middle Aged Receptors, Cell Surface - blood Reference Values Sex Factors Turkey Young Adult
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Zusammenfassung:	Increased levels of sEPCR lead to dysfunction of EPCR-mediated coagulation. The aim of this present study was to determine plasma sEPCR levels in a group of Turkish healthy population including both adults and children. The study population consisted of 230 healthy individuals (108 children and 122 adults) having no acute or chronic disease. Plasma sEPCR levels were measured with ELISA. Analysis revealed a bimodal distribution in both groups. There was a negative relationship between sEPCR levels and the age of individuals ( r = −0.385, P = 0.0001). The sEPCR levels of children were found significantly higher than that of adults ( P
ISSN:	0929-5305 1573-742X
DOI:	10.1007/s11239-009-0329-z