Central Corneal Thickness and Its Association with Ocular and General Parameters in Indians: The Central India Eye and Medical Study

Purpose To evaluate the distribution of central corneal thickness (CCT) and its associations in an adult Indian population. Design Population-based study. Participants The Central India Eye and Medical Study is a population-based study performed in a rural region close to Nagpur in Central India; it included 4711 subjects (ages 30+ years) of 5885 eligible subjects (response rate, 80.1%). Methods The participants underwent a detailed ophthalmic and medical examination, including 200 standardized questions on socioeconomic background, lifestyle, social relations, and psychiatric depression. This study was focused on CCT as measured by sonography and its associations. Intraocular pressure was measured by applanation tonometry. Main Outcome Measures Central corneal thickness and intraocular pressure. Results Central corneal thickness measurement data were available on 9370 (99.4%) eyes. Mean CCT was 514±33 μm (median, 517 μm; range, 290–696 μm). By multiple regression analysis, CCT was associated significantly with younger age ( P