Further Studies on a Human Intestinal Bacterium Ruminococcus sp. END-1 for Transformation of Plant Lignans to Mammalian Lignans
A human intestinal bacterium Ruminococcus (R.) sp. END-1 capable of oxidizing (−)-enterodiol to (−)-enterolactone, enantioselectively, was further investigated from the perspective of transformation of plant lignans to mammalian lignans; A cell-free extract of the bacterium transformed (−)-enterodio...
Gespeichert in:
| Veröffentlicht in: | Journal of agricultural and food chemistry 2009-08, Vol.57 (16), p.7537-7542 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 7542 |
|---|---|
| container_issue | 16 |
| container_start_page | 7537 |
| container_title | Journal of agricultural and food chemistry |
| container_volume | 57 |
| creator | Jin, Jong-Sik Hattori, Masao |
| description | A human intestinal bacterium Ruminococcus (R.) sp. END-1 capable of oxidizing (−)-enterodiol to (−)-enterolactone, enantioselectively, was further investigated from the perspective of transformation of plant lignans to mammalian lignans; A cell-free extract of the bacterium transformed (−)-enterodiol to (−)-enterolactone through an intermediate, enterolactol. The bacterium showed not only oxidation but also demethylation and deglucosylation activities for plant lignans. Arctiin and secoisolariciresinol diglucoside were converted to (−)-dihydroxyenterolactone and (+)-dihydroxyenterodiol, respectively. Moreover, by coincubation with Eggerthella sp. SDG-2, the bacterium transformed arctiin and secoisolariciresinol diglucoside to (−)-enterolactone and (+)-enterodiol, respectively. |
| doi_str_mv | 10.1021/jf900902p |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733836455</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733836455</sourcerecordid><originalsourceid>FETCH-LOGICAL-a434t-531266328ac14a747e103fc3a6e11b3c1c7b10ae5459f065d0418c18918c00083</originalsourceid><addsrcrecordid>eNptkT1vFDEQhi0EIkeg4A-AG4QoNszY6_0oISQk0vEhktSrOZ8dfFqvD3tdUPHXcbhVoKDxWDOPXs37DmPPEU4QBL7d2R6gB7F_wFaoBFQKsXvIVlCGVacaPGJPUtoBQKdaeMyOsG8k1KhW7Nd5jvN3E_nVnLfOJB4mTvwie5r45TSbNLuJRv6e9Gyiy55_y95NQQetc-Jpf8LPPn-okNsQ-XWkKZWPp9kVmWD515Gmma_d7VQmfA78E3lPoyviS_Mpe2RpTObZUo_ZzfnZ9elFtf7y8fL03bqiWtZzpSSKppGiI401tXVrEKTVkhqDuJEadbtBIKNq1Vto1La46zR2fXnvbMtj9vqgu4_hRy62Bu-SNmNZ0ISchlbKTja1UoV8cyB1DClFY4d9dJ7izwFhuIt7uI-7sC8W1bzxZvuXXPItwKsFoKRptCUh7dI9JwT0Qv3hXh44S2Gg21iYmysBKAGbtu7UP0qk07ALOZazpP-s9BscFJti</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733836455</pqid></control><display><type>article</type><title>Further Studies on a Human Intestinal Bacterium Ruminococcus sp. END-1 for Transformation of Plant Lignans to Mammalian Lignans</title><source>ACS Publications</source><source>MEDLINE</source><creator>Jin, Jong-Sik ; Hattori, Masao</creator><creatorcontrib>Jin, Jong-Sik ; Hattori, Masao</creatorcontrib><description>A human intestinal bacterium Ruminococcus (R.) sp. END-1 capable of oxidizing (−)-enterodiol to (−)-enterolactone, enantioselectively, was further investigated from the perspective of transformation of plant lignans to mammalian lignans; A cell-free extract of the bacterium transformed (−)-enterodiol to (−)-enterolactone through an intermediate, enterolactol. The bacterium showed not only oxidation but also demethylation and deglucosylation activities for plant lignans. Arctiin and secoisolariciresinol diglucoside were converted to (−)-dihydroxyenterolactone and (+)-dihydroxyenterodiol, respectively. Moreover, by coincubation with Eggerthella sp. SDG-2, the bacterium transformed arctiin and secoisolariciresinol diglucoside to (−)-enterolactone and (+)-enterodiol, respectively.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf900902p</identifier><identifier>PMID: 19630415</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Biological and medical sciences ; Biotransformation ; Butylene Glycols - chemistry ; Butylene Glycols - metabolism ; chemical reactions ; enterodiols ; enterolactones ; Food Chemistry/Biochemistry ; Food industries ; Fundamental and applied biological sciences. Psychology ; Furans - chemistry ; Furans - metabolism ; Glucosides - chemistry ; Glucosides - metabolism ; Humans ; intestinal microorganisms ; Intestines - microbiology ; lignans ; Lignans - chemistry ; Lignans - metabolism ; Molecular Structure ; oxidation ; plant extracts ; resinols ; Ruminococcus ; Ruminococcus - isolation & purification ; Ruminococcus - metabolism ; stereochemistry ; Stereoisomerism</subject><ispartof>Journal of agricultural and food chemistry, 2009-08, Vol.57 (16), p.7537-7542</ispartof><rights>Copyright © 2009 American Chemical Society</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a434t-531266328ac14a747e103fc3a6e11b3c1c7b10ae5459f065d0418c18918c00083</citedby><cites>FETCH-LOGICAL-a434t-531266328ac14a747e103fc3a6e11b3c1c7b10ae5459f065d0418c18918c00083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf900902p$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf900902p$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22092515$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19630415$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jin, Jong-Sik</creatorcontrib><creatorcontrib>Hattori, Masao</creatorcontrib><title>Further Studies on a Human Intestinal Bacterium Ruminococcus sp. END-1 for Transformation of Plant Lignans to Mammalian Lignans</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>A human intestinal bacterium Ruminococcus (R.) sp. END-1 capable of oxidizing (−)-enterodiol to (−)-enterolactone, enantioselectively, was further investigated from the perspective of transformation of plant lignans to mammalian lignans; A cell-free extract of the bacterium transformed (−)-enterodiol to (−)-enterolactone through an intermediate, enterolactol. The bacterium showed not only oxidation but also demethylation and deglucosylation activities for plant lignans. Arctiin and secoisolariciresinol diglucoside were converted to (−)-dihydroxyenterolactone and (+)-dihydroxyenterodiol, respectively. Moreover, by coincubation with Eggerthella sp. SDG-2, the bacterium transformed arctiin and secoisolariciresinol diglucoside to (−)-enterolactone and (+)-enterodiol, respectively.</description><subject>Biological and medical sciences</subject><subject>Biotransformation</subject><subject>Butylene Glycols - chemistry</subject><subject>Butylene Glycols - metabolism</subject><subject>chemical reactions</subject><subject>enterodiols</subject><subject>enterolactones</subject><subject>Food Chemistry/Biochemistry</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Furans - chemistry</subject><subject>Furans - metabolism</subject><subject>Glucosides - chemistry</subject><subject>Glucosides - metabolism</subject><subject>Humans</subject><subject>intestinal microorganisms</subject><subject>Intestines - microbiology</subject><subject>lignans</subject><subject>Lignans - chemistry</subject><subject>Lignans - metabolism</subject><subject>Molecular Structure</subject><subject>oxidation</subject><subject>plant extracts</subject><subject>resinols</subject><subject>Ruminococcus</subject><subject>Ruminococcus - isolation & purification</subject><subject>Ruminococcus - metabolism</subject><subject>stereochemistry</subject><subject>Stereoisomerism</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkT1vFDEQhi0EIkeg4A-AG4QoNszY6_0oISQk0vEhktSrOZ8dfFqvD3tdUPHXcbhVoKDxWDOPXs37DmPPEU4QBL7d2R6gB7F_wFaoBFQKsXvIVlCGVacaPGJPUtoBQKdaeMyOsG8k1KhW7Nd5jvN3E_nVnLfOJB4mTvwie5r45TSbNLuJRv6e9Gyiy55_y95NQQetc-Jpf8LPPn-okNsQ-XWkKZWPp9kVmWD515Gmma_d7VQmfA78E3lPoyviS_Mpe2RpTObZUo_ZzfnZ9elFtf7y8fL03bqiWtZzpSSKppGiI401tXVrEKTVkhqDuJEadbtBIKNq1Vto1La46zR2fXnvbMtj9vqgu4_hRy62Bu-SNmNZ0ISchlbKTja1UoV8cyB1DClFY4d9dJ7izwFhuIt7uI-7sC8W1bzxZvuXXPItwKsFoKRptCUh7dI9JwT0Qv3hXh44S2Gg21iYmysBKAGbtu7UP0qk07ALOZazpP-s9BscFJti</recordid><startdate>20090826</startdate><enddate>20090826</enddate><creator>Jin, Jong-Sik</creator><creator>Hattori, Masao</creator><general>American Chemical Society</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090826</creationdate><title>Further Studies on a Human Intestinal Bacterium Ruminococcus sp. END-1 for Transformation of Plant Lignans to Mammalian Lignans</title><author>Jin, Jong-Sik ; Hattori, Masao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a434t-531266328ac14a747e103fc3a6e11b3c1c7b10ae5459f065d0418c18918c00083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biological and medical sciences</topic><topic>Biotransformation</topic><topic>Butylene Glycols - chemistry</topic><topic>Butylene Glycols - metabolism</topic><topic>chemical reactions</topic><topic>enterodiols</topic><topic>enterolactones</topic><topic>Food Chemistry/Biochemistry</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Furans - chemistry</topic><topic>Furans - metabolism</topic><topic>Glucosides - chemistry</topic><topic>Glucosides - metabolism</topic><topic>Humans</topic><topic>intestinal microorganisms</topic><topic>Intestines - microbiology</topic><topic>lignans</topic><topic>Lignans - chemistry</topic><topic>Lignans - metabolism</topic><topic>Molecular Structure</topic><topic>oxidation</topic><topic>plant extracts</topic><topic>resinols</topic><topic>Ruminococcus</topic><topic>Ruminococcus - isolation & purification</topic><topic>Ruminococcus - metabolism</topic><topic>stereochemistry</topic><topic>Stereoisomerism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jin, Jong-Sik</creatorcontrib><creatorcontrib>Hattori, Masao</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jin, Jong-Sik</au><au>Hattori, Masao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Further Studies on a Human Intestinal Bacterium Ruminococcus sp. END-1 for Transformation of Plant Lignans to Mammalian Lignans</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2009-08-26</date><risdate>2009</risdate><volume>57</volume><issue>16</issue><spage>7537</spage><epage>7542</epage><pages>7537-7542</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>A human intestinal bacterium Ruminococcus (R.) sp. END-1 capable of oxidizing (−)-enterodiol to (−)-enterolactone, enantioselectively, was further investigated from the perspective of transformation of plant lignans to mammalian lignans; A cell-free extract of the bacterium transformed (−)-enterodiol to (−)-enterolactone through an intermediate, enterolactol. The bacterium showed not only oxidation but also demethylation and deglucosylation activities for plant lignans. Arctiin and secoisolariciresinol diglucoside were converted to (−)-dihydroxyenterolactone and (+)-dihydroxyenterodiol, respectively. Moreover, by coincubation with Eggerthella sp. SDG-2, the bacterium transformed arctiin and secoisolariciresinol diglucoside to (−)-enterolactone and (+)-enterodiol, respectively.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>19630415</pmid><doi>10.1021/jf900902p</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8561 |
| ispartof | Journal of agricultural and food chemistry, 2009-08, Vol.57 (16), p.7537-7542 |
| issn | 0021-8561 1520-5118 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733836455 |
| source | ACS Publications; MEDLINE |
| subjects | Biological and medical sciences Biotransformation Butylene Glycols - chemistry Butylene Glycols - metabolism chemical reactions enterodiols enterolactones Food Chemistry/Biochemistry Food industries Fundamental and applied biological sciences. Psychology Furans - chemistry Furans - metabolism Glucosides - chemistry Glucosides - metabolism Humans intestinal microorganisms Intestines - microbiology lignans Lignans - chemistry Lignans - metabolism Molecular Structure oxidation plant extracts resinols Ruminococcus Ruminococcus - isolation & purification Ruminococcus - metabolism stereochemistry Stereoisomerism |
| title | Further Studies on a Human Intestinal Bacterium Ruminococcus sp. END-1 for Transformation of Plant Lignans to Mammalian Lignans |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T07%3A38%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Further%20Studies%20on%20a%20Human%20Intestinal%20Bacterium%20Ruminococcus%20sp.%20END-1%20for%20Transformation%20of%20Plant%20Lignans%20to%20Mammalian%20Lignans&rft.jtitle=Journal%20of%20agricultural%20and%20food%20chemistry&rft.au=Jin,%20Jong-Sik&rft.date=2009-08-26&rft.volume=57&rft.issue=16&rft.spage=7537&rft.epage=7542&rft.pages=7537-7542&rft.issn=0021-8561&rft.eissn=1520-5118&rft.coden=JAFCAU&rft_id=info:doi/10.1021/jf900902p&rft_dat=%3Cproquest_cross%3E733836455%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733836455&rft_id=info:pmid/19630415&rfr_iscdi=true |