Haptoglobin genotypes in Chagas' disease

Objectives: To investigate the existence of an association between haptoglobin (Hp) genotypes and the severity of heart complications in Chagas' disease. Design and methods: Hp genotyping was performed by PCR in 107 Brazilian patients sub-classified in asymptomatic, with mild heart disease and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical biochemistry 2010-02, Vol.43 (3), p.314-316
Hauptverfasser:	Jorge, Susan E.D.C., Abreu, Cristina Feix, Guariento, Maria Elena, Sonati, Maria de Fatima
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brazil Cardiomyopathies Chagas Cardiomyopathy - genetics Chagas Cardiomyopathy - physiopathology Chagas Disease - complications Chagas Disease - genetics Chagas' disease Genotype Haptoglobin Haptoglobins - genetics Human protozoal diseases Humans Infectious diseases Medical sciences Parasitic diseases Protozoal diseases Risk Factors Trypanosoma cruzi Trypanosomiasis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Objectives: To investigate the existence of an association between haptoglobin (Hp) genotypes and the severity of heart complications in Chagas' disease. Design and methods: Hp genotyping was performed by PCR in 107 Brazilian patients sub-classified in asymptomatic, with mild heart disease and with severe heart disease. Results: Multiple logistic regression ( R 2 = 24%) indicated that patients with the Hp1-1 genotype have lower probability of developing the severe heart complications. Conclusion: The Hp polymorphism may influence the clinical evolution of Chagas' disease.
ISSN:	0009-9120 1873-2933
DOI:	10.1016/j.clinbiochem.2009.09.020