Diastereoselective and enantioselective Mukaiyama aldol reactions of alpha-ketoesters using hydrogen bond catalysis

Diastereoselective and enantioselective Mukaiyama aldol reactions of alpha-ketoesters using hydrogen bond catalysis

Hydrogen bond catalyzed Mukaiyama aldol reactions of alpha-ketoesters proceed in high diastereo- and enantioselectivities, giving products possessing two chiral centers, of which one is a tertiary alcohol.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2010-01, Vol.46 (6), p.904-906
Hauptverfasser: Gondi, Vijaya Bhasker, Hagihara, Koji, Rawal, Viresh H
Format: Artikel
Sprache:eng
Schlagworte:
Acetals - chemistry
Catalysis
Ethylenes - chemistry
Hydrogen Bonding
Ketones - chemistry
Pyruvic Acid - chemistry
Stereoisomerism
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Zusammenfassung:Hydrogen bond catalyzed Mukaiyama aldol reactions of alpha-ketoesters proceed in high diastereo- and enantioselectivities, giving products possessing two chiral centers, of which one is a tertiary alcohol.
ISSN:1359-7345
1364-548X
DOI:10.1039/b919929b