Cytohistologic correlation rates between conventional Papanicolaou smears and ThinPrep cervical cytology: A comparison

BACKGROUND The ThinPrep® Papanicolaou (Pap) test, a liquid‐based alternative to the long‐used conventional Pap smear, received Food and Drug Administration approval in 1996. The current study is a comparison of the accuracy, as assessed by cytohistologic correlation, of conventional versus ThinPrep® Pap smears in a hospital setting. METHODS A retrospective analysis of all patients who underwent Pap smears (conventional and ThinPrep) and pertinent surgical pathology tissue processed in our department over a 1‐year period was undertaken. Tissue diagnoses were grouped into broad general categories to correlate with the Bethesda system. The statistical significance of differences between the two types of Pap test results compared with tissue diagnoses was assessed using a chi‐square test with 1 degree of freedom and an α value of 0.05. RESULTS Of the 65,421 Pap smears interpreted during the study period, histologic correlation was possible in 1544 patients. Of those diagnosed as negative (644 conventional and 245 ThinPrep Smears), low‐grade squamous intraepithelial lesion (LGSIL) (116 conventional and 114 ThinPrep smears), and high‐grade squamous intraepithelial lesions (HGSIL) (142 conventional and 131 ThinPrep smears), there was no statistically significant difference found between the correlation rates of conventional and ThinPrep Pap smear results. However, review of all cases of invasive cervical carcinoma identified during this time period showed the ThinPrep to be less consistent in predicting the presence of invasive carcinoma compared with the conventional Pap smear. CONCLUSIONS Based on cytohistologic correlation evidence, the ThinPrep Pap test may not be more effective in detecting cervical disease, particularly invasive carcinoma, when compared with the conventional Pap smear. Cancer (Cancer Cytopathol) 2003;99:135–40. © 2003 American Cancer Society. The conventional Papanicolaou (Pap) smear has been in widespread use since the 1950s. However, in 1996 the Food and Drug Administration approved the ThinPrep Pap Test, which was intended to be a replacement for the Pap smear. In the current study, the authors compare the accuracy of the two methods using cytohistologic correlation.