Liquid chromatographic determination of the known low level impurities in lovastatin bulk drug: An application of high—low chromatography

High—low chromatography in combination with gradient elution and multiple wavelength detection is a rapid and sensitive technique that can be used to assay low level impurities in lovastatin. The method is reproducible and can be applied to samples containing as little as 0.1% of any known impurity....

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Veröffentlicht in:Talanta (Oxford) 1993-04, Vol.40 (4), p.491-494
Hauptverfasser: Houck, Anthony, Thomas, Scott, Ellison, Dean K.
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container_title Talanta (Oxford)
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creator Houck, Anthony
Thomas, Scott
Ellison, Dean K.
description High—low chromatography in combination with gradient elution and multiple wavelength detection is a rapid and sensitive technique that can be used to assay low level impurities in lovastatin. The method is reproducible and can be applied to samples containing as little as 0.1% of any known impurity.
doi_str_mv 10.1016/0039-9140(93)80005-C
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source Elsevier ScienceDirect Journals
subjects Analysis
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacology. Drug treatments
title Liquid chromatographic determination of the known low level impurities in lovastatin bulk drug: An application of high—low chromatography
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