Liquid chromatographic determination of the known low level impurities in lovastatin bulk drug: An application of high—low chromatography

Liquid chromatographic determination of the known low level impurities in lovastatin bulk drug: An application of high—low chromatography

High—low chromatography in combination with gradient elution and multiple wavelength detection is a rapid and sensitive technique that can be used to assay low level impurities in lovastatin. The method is reproducible and can be applied to samples containing as little as 0.1% of any known impurity....

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Veröffentlicht in:Talanta (Oxford) 1993-04, Vol.40 (4), p.491-494
Hauptverfasser: Houck, Anthony, Thomas, Scott, Ellison, Dean K.
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacology. Drug treatments
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Zusammenfassung:High—low chromatography in combination with gradient elution and multiple wavelength detection is a rapid and sensitive technique that can be used to assay low level impurities in lovastatin. The method is reproducible and can be applied to samples containing as little as 0.1% of any known impurity.
ISSN:0039-9140
1873-3573
DOI:10.1016/0039-9140(93)80005-C