Spectrophotometric determination of Diclofenac sodium with Methylene Blue

Spectrophotometric determination of Diclofenac sodium with Methylene Blue

A sensitive spectrophotometric method was established for the determination of Diclofenac sodium (DS) with Methylene Blue (MB) as analytical reagent. It was found that DS reacts with an excess of MB in the pH range 9.2–9.4, to form a chloroform-extractable blue ion-association complex. Good agreemen...

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Veröffentlicht in:Talanta (Oxford) 1995, Vol.42 (1), p.105-108
Hauptverfasser: Botello, Julio C., Pérez-Caballero, Guadalupe
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacology. Drug treatments
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Zusammenfassung:A sensitive spectrophotometric method was established for the determination of Diclofenac sodium (DS) with Methylene Blue (MB) as analytical reagent. It was found that DS reacts with an excess of MB in the pH range 9.2–9.4, to form a chloroform-extractable blue ion-association complex. Good agreement with Beer's law was found in the range of DS concentrations of 0.8–6.4 μg/ml with a detection limit of 0.37 μg/ml. The method was applied for the determination of DS in various tableted forms with a good precision.
ISSN:0039-9140
1873-3573
DOI:10.1016/0039-9140(94)00224-G