Flow-injection fluorimetric analysis of sulfamethoxazole in pharmaceutical preparations and biological fluids

A fluorimetric procedure for the determination of sulfamethoxazole using flow injection analysis is proposed. A two channel system is optimized for the fluorescent reaction with o-phthaldialdehyde and β-mercaptoethanol. The detection limit is 0.007 μg/ml. No fluorescence is generated by the metaboli...

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Veröffentlicht in:	Talanta (Oxford) 1994-12, Vol.41 (12), p.2159-2164
Hauptverfasser:	Erroz, C.Lopez, Viñas, P., Córdoba, M.Hernández
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biological and medical sciences General pharmacology Medical sciences Pharmacology. Drug treatments
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Zusammenfassung:	A fluorimetric procedure for the determination of sulfamethoxazole using flow injection analysis is proposed. A two channel system is optimized for the fluorescent reaction with o-phthaldialdehyde and β-mercaptoethanol. The detection limit is 0.007 μg/ml. No fluorescence is generated by the metabolite N-acetylated sulfamethoxazole. The method is applied to the determination of sulfamethoxazole in pharmaceuticals, urine and bovine serum samples without matrix interference problems.
ISSN:	0039-9140 1873-3573
DOI:	10.1016/0039-9140(94)00203-7